Biological Activity of Some Monocyclic- and Bicyclic β-Lactams with Specified Functional Groups

被引：43

作者：

Hwu, Jih Ru ^{[1
,2
]}

Ethiraj, Krishna S. ^{[2
]}

Hakimelahi, Gholam H. ^{[1
]}

机构：

[1] Acad Sinica, Inst Chem, Organosilicon & Synth Lab, Taipei 11529, Taiwan

[2] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 04期

关键词：

D O I：

10.2174/1389557033488132

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This Review contains our recent studies on evaluation of biological activities associated with monocyclic beta-lactams and bicyclic beta-lactam antibiotics containing various heteroatoms. A series of bicyclic beta-lactams was synthesized, which possessed electron-withdrawing groups, such as an ester, mesylate, and triflate functionality. These beta-lactams exhibited enhanced antibacterial activity.

引用

页码：305 / 313

页数：9

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