NH4I-promoted N-acylation of amines via the transamidation of DMF and DMA under metal-free conditions

被引：23

作者：

Chen, Jiahui ^{[1
]}

Jia, Jing ^{[1
]}

Guo, Ziyi ^{[1
]}

Zhang, Jitan ^{[1
]}

Xie, Meihua ^{[1
]}

机构：

[1] Anhui Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Mol Solids, Anhui Key Lab Mol Based Mat,Minist Educ, Wuhu 241002, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Transamidation; Amines; N-Acylation; NH4I; CARBOXYLIC-ACIDS; MAGNETIC NANOPARTICLES; FORMYLATION; AMIDES; AMIDATION; CATALYST; N; N-DIMETHYLFORMAMIDE; CARBOXAMIDES; ACCESS;

D O I：

10.1016/j.tetlet.2019.04.040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented NH4I-promoted N-formylation and N-acetylization of various amines with dimethylformamide (DMF) and dimethylacetamide (DMA) has been developed. This protocol shows broad substrate scope for aromatic, aliphatic, and heterocyclic amines, which provides a metal-free strategy for N-acylation featuring mild reaction conditions, as well as inexpensive and readily available starting materials. (C) 2019 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1426 / 1429

页数：4

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