Survival of retinal ganglion cells after damage to the occipital lobe in humans is activity dependent

被引:22
作者
Schneider, Colleen L. [1 ,2 ,3 ]
Prentiss, Emily K. [4 ]
Busza, Ania [4 ]
Matmati, Kelly [7 ]
Matmati, Nabil [7 ]
Williams, Zoe R. [4 ,5 ,6 ]
Sahin, Bogachan [4 ]
Mahon, Bradford Z. [3 ,4 ,6 ,8 ]
机构
[1] Univ Rochester, Dept Brain & Cognit Sci, 601 Elmwood Ave, Rochester, NY 14627 USA
[2] Univ Rochester, Sch Med & Dent, Med Scientist Training Program, Rochester, NY 14642 USA
[3] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15206 USA
[4] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA
[5] Univ Rochester, Med Ctr, Dept Ophthalmol, Rochester, NY 14642 USA
[6] Univ Rochester, Med Ctr, Dept Neurosurg, Rochester, NY 14642 USA
[7] Rochester Reg Hlth, Dept Neurol, Rochester, NY 14621 USA
[8] Univ Rochester, Ctr Visual Sci, 601 Elmwood Ave, Rochester, NY 14642 USA
关键词
stroke; homonymous hemianopia; retinal ganglion cells; optical coherence tomography; functional magnetic resonance imaging; retinotopic mapping; TRANSNEURONAL RETROGRADE DEGENERATION; NEUROTROPHIC FACTOR; VISUAL-CORTEX; OPTIC TRACT; V1; EXPRESSION; RECOVERY; VISION; INPUT; AREAS;
D O I
10.1098/rspb.2018.2733
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Damage to the optic radiations or primary visual cortex leads to blindness in all or part of the contralesional visual field. Such damage disconnects the retina from its downstream targets and, over time, leads to trans-synaptic retrograde degeneration of retinal ganglion cells. To date, visual ability is the only predictor of retinal ganglion cell degeneration that has been investigated after geniculostriate damage. Given prior findings that some patients have preserved visual cortex activity for stimuli presented in their blind field, we tested whether that activity explains variability in retinal ganglion cell degeneration over and above visual ability. We prospectively studied 15 patients (four females, mean age = 63.7 years) with homonymous visual field defects secondary to stroke, 10 of whom were tested within the first two months after stroke. Each patient completed automated Humphrey visual field testing, retinotopic mapping with functional magnetic resonance imaging, and spectral-domain optical coherence tomography of the macula. There was a positive relation between ganglion cell complex (GCC) thickness in the blind field and early visual cortex activity for stimuli presented in the blind field. Furthermore, residual visual cortex activity for stimuli presented in the blind field soon after the stroke predicted the degree of retinal GCC thinning six months later. These findings indicate that retinal ganglion cell survival after ischaemic damage to the geniculostriate pathway is activity dependent.
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页数:9
相关论文
共 38 条
[1]  
Baseler HA, 1999, J NEUROSCI, V19, P2619
[2]   Voxel-based lesion-symptom mapping [J].
Bates, E ;
Wilson, SM ;
Saygin, AP ;
Dick, F ;
Sereno, MI ;
Knight, RT ;
Dronkers, NF .
NATURE NEUROSCIENCE, 2003, 6 (05) :448-450
[3]   Imaging Reveals Optic Tract Degeneration in Hemianopia [J].
Bridge, Holly ;
Jindahra, Panitha ;
Barbur, John ;
Plant, Gordon T. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2011, 52 (01) :382-388
[4]   INHIBITION OF OCULAR DOMINANCE COLUMN FORMATION BY INFUSION OF NT-4/5 OR BDNF [J].
CABELLI, RJ ;
HOHN, A ;
SHATZ, CJ .
SCIENCE, 1995, 267 (5204) :1662-1666
[5]   LIGHT REGULATES EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA IN RAT VISUAL-CORTEX [J].
CASTREN, E ;
ZAFRA, F ;
THOENEN, H ;
LINDHOLM, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9444-9448
[6]   Visual discrimination training improves Humphrey perimetry in chronic cortically induced blindness [J].
Cavanaugh, Matthew R. ;
Huxlin, Krystel R. .
NEUROLOGY, 2017, 88 (19) :1856-1864
[7]   Visual recovery in cortical blindness is limited by high internal noise [J].
Cavanaugh, Matthew R. ;
Zhang, Ruyuan ;
Melnick, Michael D. ;
Das, Anasuya ;
Roberts, Marie ;
Tadin, Duje ;
Carrasco, Marisa ;
Huxlin, Krystel R. .
JOURNAL OF VISION, 2015, 15 (10)
[8]   Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans [J].
Cowey, Alan ;
Alexander, Iona ;
Stoerig, Petra .
BRAIN, 2011, 134 :2149-2157
[9]   Long-Term Protection of Retinal Ganglion Cells and Visual Function by Brain-Derived Neurotrophic Factor in Mice With Ocular Hypertension [J].
Feng, Liang ;
Chen, Hui ;
Yi, Ji ;
Troy, John B. ;
Zhang, Hao F. ;
Liu, Xiaorong .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (08) :3793-3802
[10]  
Fournier AE, 1997, J NEUROSCI RES, V47, P561, DOI 10.1002/(SICI)1097-4547(19970315)47:6<561::AID-JNR1>3.3.CO