Vascular permeability changes involved in tumor metastasis

被引：120

作者：

Garcia-Roman, Jonathan ^{[1
]}

Zentella-Dehesa, Alejandro ^{[1
,2
]}

机构：

[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Bioquim, Colonia Secc 16, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Insituto Invest Biomed, Mexico City 04510, DF, Mexico

来源：

CANCER LETTERS | 2013年 / 335卷 / 02期

关键词：

Vascular permeability; Metastasis; Vasoactive compounds; Endothelial cells; VEGF; Angptl4; BREAST-CANCER CELLS; ENDOTHELIAL GROWTH-FACTOR; LEUKOCYTE TRANSENDOTHELIAL MIGRATION; LIGHT-CHAIN PHOSPHORYLATION; TIGHT JUNCTION BARRIER; FOCAL ADHESION KINASE; CARCINOMA-CELLS; VE-CADHERIN; STEM-CELLS; PANCREATIC-CANCER;

D O I：

10.1016/j.canlet.2013.03.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer cell extravasation resembles the leukocyte recruitment during inflammation. Evidence suggests that cancer cells need to weaken the interendothelial junctions in order to cross the endothelial barrier. Several tumor-derived vasoactive compounds have been pointed out to drive this increase in vascular permeability: VEGF, Angptl4, CCL2, SDF-1, etc. Therefore, tumor cells have a wide repertoire of soluble factors to increase vascular permeability in order to colonize new tissues. Tumor soluble factors activate different signaling pathways to induce interendothelial junction disassembly, one common element is Src kinase. Here we summarize the relevant current knowledge about vascular permeability changes involved in tumor metastasis. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：259 / 269

页数：11

共 123 条

[1] Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration [J].