Functional Dyspepsia: Clinical Symptoms, Psychological Findings, and GCSI Scores

被引:28
作者
Lacy, Brian E. [1 ]
Everhart, Kelly [2 ]
Crowell, Michael D. [3 ]
机构
[1] Mayo Clin, Div Gastroenterol & Hepatol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
[2] Dartmouth Hitchcock Med Ctr, Div Gastroenterol & Hepatol, Lebanon, NH 03766 USA
[3] Mayo Clin, Scottsdale, AZ USA
关键词
Dyspepsia; Functional dyspepsia; Gastroparesis; GCSI; Nausea; QUALITY-OF-LIFE; GASTROINTESTINAL SYMPTOMS; DIABETIC GASTROPARESIS; UNITED-STATES; OUTCOMES; INDEX; PREVALENCE; HOSPITALIZATIONS; MULTICENTER; MANAGEMENT;
D O I
10.1007/s10620-018-5347-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BackgroundThe GCSI questionnaire measures symptoms of gastroparesis (GP). Symptoms of FD overlap with GP. The ability of the GCSI to discriminate FD from GP is unknown.AimsBy prospectively evaluating functional dyspepsia (FD) patients, we aimed to evaluate the ability of the Gastroparesis Cardinal Symptom Index (GCSI) to: (1) distinguish FD from GP; (2) predict symptom severity, anxiety, and depression; (3) correlate symptoms with gastric emptying.MethodsFD patients (Rome III criteria) were identified, and upper endoscopy and gastric emptying scan (GES) data recorded. A total of 254 patients were mailed a questionnaire evaluating demographics, FD symptoms, mental well-being; the GCSI was included.ResultsOne hundred and twenty-three patients responded; of them, 75% were women and mean age was 49 (15 SD) years. 44.7% were categorized as postprandial distress subtype (PDS), 34.1% were epigastric pain subtype (EPS), and 21.1% were mixed type. The mean GCSI score was 2.02 (1.1 SD), slightly lower than historical GP controls (2.26-2.56). Mixed EPS-PDS subtype had the lowest GCSI scores (1.79; 0.91 SD). Bloating was the highest GCSI subscore (2.70; 1.53 SD), followed by fullness (2.31; 1.39 SD) and nausea (1.08; 1.19 SD). The GCSI total score did not correlate with anxiety and depression scores or with 4-h gastric emptying.ConclusionsIn this population of FD patients, GCSI scores were slightly lower than historical gastroparesis control patients, although within the reported range. These results suggest that the GCSI cannot accurately distinguish FD patients from GP patients. A more specific questionnaire is needed to aid in the diagnosis and management of these distinct gastrointestinal disorders.
引用
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页码:1281 / 1287
页数:7
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