Repetitive Transcranial Magnetic Stimulation (rTMS) for the cognitive rehabilitation of traumatic brain injury (TBI) victims: study protocol for a randomized controlled trial

被引:27
作者
Neville, Iuri Santana [1 ,2 ,5 ]
Hayashi, Cintya Yukie [2 ,3 ]
El Hajj, Simone Alves [4 ]
Costa Zaninotto, Ana Luiza [2 ,4 ]
Sabino, Juliana Perez [4 ]
Sousa, Leonardo Moura, Jr. [1 ,2 ,5 ]
Nagumo, Marcia Mitie [2 ]
Brunoni, Andre Russowsky [2 ,5 ]
Silva Shieh, Barbara Dal Forno [4 ]
Oliveira Amorim, Robson Luis [1 ,2 ,5 ]
Teixeira, Manoel Jacobsen [1 ,2 ,5 ]
Paiva, Wellingson Silva [1 ,2 ,5 ]
机构
[1] Univ Sao Paulo, Hosp Clin, Div Neurosurg, BR-05403010 Sao Paulo, SP, Brazil
[2] Univ Sao Paulo, Serv Interdisciplinary Neuromodulat, BR-05403010 Sao Paulo, SP, Brazil
[3] Univ Sao Paulo, Sch Nursing, BR-05403010 Sao Paulo, SP, Brazil
[4] Univ Sao Paulo, Hosp Clin, Div Neuropsychol, BR-05403010 Sao Paulo, SP, Brazil
[5] Univ Sao Paulo, Hosp Clin, Inst Psychiat, BR-05403010 Sao Paulo, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
Brain Injury; Cognition; Cognitive; Diffuse Axonal Injury; Non-invasive brain stimulation; Psychology; Repetitive transcranial magnetic stimulation (TMS; rTMS); DIFFUSE AXONAL INJURY; QUALITY-OF-LIFE; ANXIETY INVENTORY; HEAD-INJURY; IMPAIRMENT; DEPRESSION; INTEGRITY; MODERATE; DAMAGE;
D O I
10.1186/s13063-015-0944-2
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Repetitive Transcranial Magnetic Stimulation (rTMS) has been proposed as a new tool in neurological rehabilitation of victims of traumatic brain injury (TBI). However, its usefulness to treat this condition has never been tested rigorously. The primary goal is to conduct a study protocol to determine whether rTMS used to cognitive rehabilitation of victims of TBI with diffuse axonal injury (DAI) is a safe instrument and if it enhances cognitive function recovery. Methods: Double-blind randomized controlled trial of patients with diffuse axonal injury. Thirty-six patients will be randomized to either an active coil group or sham group in a 1: 1 ratio. rTMS protocol: 10 sessions of high-frequency rTMS (10 Hz) over the left dorsolateral prefrontal cortex (DLPFC). Cortical Excitability measures will be obtained. Neuropsychological evaluations will be performed 1 week before, 1 week and 3 months after rTMS. There are 2 study hypotheses: (1) rTMS over the left DLPFC in patients with DAI will improve cognitive function and (2) whether rTMS is safe in TBI patients. Discussion: This study evaluates the immediate and delayed effects of rTMS over the DLPFC on the cognitive domain of patients with DAI following TBI. rTMS has shown good results in treating major depression and may be promising for patients with TBI. As such, the results of this study can greatly modify the cognitive rehabilitation strategies.
引用
收藏
页数:7
相关论文
共 41 条
[1]   DIFFUSE AXONAL INJURY DUE TO NONMISSILE HEAD-INJURY IN HUMANS - AN ANALYSIS OF 45 CASES [J].
ADAMS, JH ;
GRAHAM, DI ;
MURRAY, LS ;
SCOTT, G .
ANNALS OF NEUROLOGY, 1982, 12 (06) :557-563
[2]   Cognitive effects of repetitive transcranial magnetic stimulation in patients with neurodegenerative diseases - Clinician's perspective [J].
Anderkova, Lubomira ;
Rektorova, Irena .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2014, 339 (1-2) :15-25
[3]  
[Anonymous], 1998, A Compendium of Neuropsychological Tests
[4]  
[Anonymous], 1998, Manual for the Wechsler Adult Intelligence Scale
[5]   Can Repetitive Magnetic Stimulation Improve Cognition in Schizophrenia? Pilot Data from a Randomized Controlled Trial [J].
Barr, Mera S. ;
Farzan, Faranak ;
Rajji, Tarek K. ;
Voineskos, Aristotle N. ;
Blumberger, Daniel M. ;
Arenovich, Tamara ;
Fitzgerald, Paul B. ;
Daskalakis, Zafiris J. .
BIOLOGICAL PSYCHIATRY, 2013, 73 (06) :510-517
[6]   An efficient and accurate new method for locating the F3 position for prefrontal TMS applications [J].
Beam, William ;
Borckardt, Jeffrey J. ;
Reeves, Scott T. ;
George, Mark S. .
BRAIN STIMULATION, 2009, 2 (01) :50-54
[7]   RELATIONSHIP BETWEEN THE BECK ANXIETY INVENTORY AND THE HAMILTON ANXIETY RATING-SCALE WITH ANXIOUS OUTPATIENTS [J].
BECK, AT ;
STEER, RA .
JOURNAL OF ANXIETY DISORDERS, 1991, 5 (03) :213-223
[8]  
Benedict R.H., 1997, BRIEF VISUOSPATIAL M
[9]   Hopkins Verbal Learning Test Revised: Normative data and analysis of inter-form and test-retest reliability [J].
Benedict, RHB ;
Schretlen, D ;
Groninger, L ;
Brandt, J .
CLINICAL NEUROPSYCHOLOGIST, 1998, 12 (01) :43-55
[10]   Theta burst stimulation improves visuo-spatial attention in a patient with traumatic brain injury [J].
Bonni, Sonia ;
Mastropasqua, Chiara ;
Bozzali, Marco ;
Caltagirone, Carlo ;
Koch, Giacomo .
NEUROLOGICAL SCIENCES, 2013, 34 (11) :2053-2056