Manipulation of viral infection by deubiquitinating enzymes: new players in host-virus interactions

被引：12

作者：

Gu, Zhiwen ^{[1
]}

Shi, Weifeng ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 3, Dept Lab Med, Changzhou 213003, Jiangsu, Peoples R China

来源：

FUTURE MICROBIOLOGY | 2016年 / 11卷 / 11期

基金：

中国国家自然科学基金;

关键词：

deubiquitinating enzymes; deubiquitinase inhibitors; post-translational modification; ubiquitin smystem; viruses; NF-KAPPA-B; PAPAIN-LIKE PROTEASE; INNATE IMMUNE-RESPONSE; MEDIATED ANTIVIRAL RESPONSE; SMALL-MOLECULE INHIBITOR; TUMOR-SUPPRESSOR CYLD; I-LIKE RECEPTORS; RIG-I; MULTIPLE-MYELOMA; UBIQUITIN LIGASE;

D O I：

10.2217/fmb-2016-0091

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ubiquitination regulates gene expression post-translationally through the well-characterized ubiquitin system, which has been clearly established to have important functions in the regulation of many intracellular biological activities. Being obligate intracellular microbes, viruses inevitably co-opt this conserved host cytosolic machinery to accomplish their own life cycle, from entry into host cells to the release of progeny viral particles. Deubiquitinating enzymes (DUBs) remove ubiquitins from target proteins to reverse the modification of ubiquitination, and thusly affect a great number of signaling pathways, as well as viral infections. This review presents what is known about how viruses bypass or employ DUBs to evade host immune defenses and discusses new therapeutic strategies targeting DUBs for diseases treatment.

引用

页码：1435 / 1446

页数：12