Diabetes and breast cancer risk: a meta-analysis

被引：239

作者：

Boyle, P. ^{[1
]}

Boniol, M. ^{[1
]}

Koechlin, A. ^{[1
]}

Robertson, C. ^{[1
,2
]}

Valentini, F. ^{[1
]}

Coppens, K. ^{[1
]}

Fairley, L-L ^{[1
]}

Boniol, M. ^{[1
]}

Zheng, T. ^{[3
]}

Zhang, Y. ^{[3
]}

Pasterk, M. ^{[1
]}

Smans, M. ^{[1
]}

Curado, M. P. ^{[1
]}

Mullie, P. ^{[1
]}

Gandini, S. ^{[1
,4
]}

Bota, M. ^{[1
]}

Bolli, G. B. ^{[5
]}

Rosenstock, J. ^{[6
]}

Autier, P. ^{[1
]}

机构：

[1] Int Prevent Res Inst, F-69006 Lyon, France

[2] Univ Strathclyde, Dept Math & Stat, Glasgow G1 1XH, Lanark, Scotland

[3] Yale Univ, Sch Publ Hlth, New Haven, CT 06520 USA

[4] European Inst Oncol, I-20146 Milan, Italy

[5] Univ Perugia, SM della Misericordia Hosp, Dept Internal Med & Oncol, I-06132 Perugia, Italy

[6] Dallas Diabet & Endocrine Ctr Med City, Dallas, TX 75230 USA

来源：

BRITISH JOURNAL OF CANCER | 2012年 / 107卷 / 09期

关键词：

diabetes; breast cancer; meta-analysis; body mass index; POPULATION-BASED COHORT; HORMONE-BINDING GLOBULIN; MEDICAL CONDITIONS; FOLLOW-UP; POSTMENOPAUSAL WOMEN; PUBLICATION BIAS; US ADULTS; MELLITUS; INSULIN; MORTALITY;

D O I：

10.1038/bjc.2012.414

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: The potential of an increased risk of breast cancer in women with diabetes has been the subject of a great deal of recent research. METHODS: A meta-analysis was undertaken using a random effects model to investigate the association between diabetes and breast cancer risk. RESULTS: Thirty-nine independent risk estimates were available from observational epidemiological studies. The summary relative risk (SRR) for breast cancer in women with diabetes was 1.27 (95% confidence interval (CI), 1.16-1.39) with no evidence of publication bias. Prospective studies showed a lower risk (SRR 1.23 (95% CI, 1.12-1.35)) than retrospective studies (SRR 1.36 (95% CI, 1.13-1.63)). Type 1 diabetes, or diabetes in pre-menopausal women, were not associated with risk of breast cancer (SRR 1.00 (95% CI, 0.74-1.35) and SRR 0.86 (95% CI, 0.66-1.12), respectively). Studies adjusting for body mass index (BMI) showed lower estimates (SRR 1.16 (95% CI, 1.08-1.24)) as compared with those studies that were not adjusted for BMI (SRR 1.33 (95% CI, 1.18-1.51)). CONCLUSION: The risk of breast cancer in women with type 2 diabetes is increased by 27%, a figure that decreased to 16% after adjustment for BMI. No increased risk was seen for women at pre-menopausal ages or with type 1 diabetes. British Journal of Cancer (2012) 107, 1608-1617. doi:10.1038/bjc.2012.414 www.bjcancer.com Published online 20 September 2012 (C) 2012 Cancer Research UK

引用

页码：1608 / 1617

页数：10

共 78 条

[1] CANCER RISK IN PATIENTS WITH DIABETES-MELLITUS [J].