Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology

被引：61
作者：
Wang, Hui-Fu [1 ,2 ,3 ]
Zhang, Wei [1 ,2 ]
Rolls, Edmund T. [1 ,2 ,4 ,5 ]
Li, Yuzhu [1 ,2 ]
Wang, Linbo [1 ,2 ]
Ma, Ya-Hui [3 ]
Kang, Jujiao [1 ,2 ]
Feng, Jianfeng [1 ,2 ,6 ,7 ,8 ]
Yu, Jin-Tai [1 ,2 ]
Cheng, Wei [1 ,2 ,6 ,8 ]
机构：
[1] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, State Key Lab Med Neurobiol, Dept Neurol,Huashan Hosp, Shanghai, Peoples R China
[2] Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai, Peoples R China
[3] Qingdao Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China
[4] Univ Warwick, Dept Comp Sci, Coventry CV4 7AL, W Midlands, England
[5] Oxford Ctr Computat Neurosci, Oxford, England
[6] Fudan Univ, Minist Educ, Key Lab Computat Neurosci & Brain Inspired Intell, Shanghai, Peoples R China
[7] Zhangjiang Fudan Int Innovat Ctr, Shanghai, Peoples R China
[8] Zhejiang Normal Univ, Fudan ISTBI ZJNU Algorithm Ctr Brain Inspired Int, Jinhua, Zhejiang, Peoples R China
来源：
EBIOMEDICINE | 2022年 / 86卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Hearing impairment; Cognitive decline; Brain atrophy; CSF tau protein; CENTRAL AUDITORY DYSFUNCTION; ALZHEIMERS-DISEASE; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; OLDER-ADULTS; SCENE ANALYSIS; DEMENTIA; RECOMMENDATIONS; WORKGROUPS; BIOMARKERS;
D O I：
10.1016/j.ebiom.2022.104336
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background Hearing impairment was recently identified as the most prominent risk factor for dementia. However, the mechanisms underlying the link between hearing impairment and dementia are still unclear. Methods We investigated the association of hearing performance with cognitive function, brain structure and cerebrospinal fluid (CSF) proteins in cross-sectional, longitudinal, mediation and genetic association analyses across the UK Biobank (N = 165,550), the Chinese Alzheimer's Biomarker and Lifestyle (CABLE, N = 863) study, and the Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 1770) database. Findings Poor hearing performance was associated with worse cognitive function in the UK Biobank and in the CABLE study. Hearing impairment was significantly related to lower volume of temporal cortex, hippocampus, inferior parietal lobe, precuneus, etc., and to lower integrity of white matter (WM) tracts. Furthermore, a higher polygenic risk score (PRS) for hearing impairment was strongly associated with lower cognitive function, lower volume of gray matter, and lower integrity of WM tracts. Moreover, hearing impairment was correlated with a high level of CSF tau protein in the CABLE study and in the ADNI database. Finally, mediation analyses showed that brain atrophy and tau pathology partly mediated the association between hearing impairment and cognitive decline. Interpretation Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology, and hearing impairment may reflect the risk for cognitive decline and dementia as it is related to bran atrophy and tau accumulation in brain. However, it is necessary to assess the mechanism in future animal studies. Copyright (C) 2022 The Author(s). Published by Elsevier B.V.
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页数：13
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