The combination of insulin and GLP-1 analogues in the treatment of type 2 diabetes

被引：0

作者：

van der Klauw, M. M. ^{[1
]}

Wolffenbuttel, B. H. R. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands

来源：

NETHERLANDS JOURNAL OF MEDICINE | 2012年 / 70卷 / 10期

关键词：

GLP-1; analogue; review; diabetes mellitus; insulin; combination; EXENATIDE THERAPY; TREATED PATIENTS; GLYCEMIC CONTROL; LIRAGLUTIDE; GLARGINE; ASSOCIATION; METFORMIN; EFFICACY; OUTCOMES; GLUCOSE;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

GLP-1 analogues have been proven to be effective in the treatment of type 2 diabetes mellitus. They stimulate insulin production and secretion, and suppress glucagon secretion, depending on the blood glucose level. They also have an effect on the brain, enhancing satiety, and on the gut, where they delay gastric emptying. Theoretically, in type 2 diabetes mellitus patients, the combination of a GLP-1 analogue with insulin seems attractive, because of the weight loss perceived in users of GLP-1 analogues in contrast to the weight gain seen in most patients starting insulin therapy, leading to even more insulin resistance. There are only a few randomised controlled trials which have studied this combination and several uncontrolled studies, which will be reviewed here.

引用

页码：436 / 443

页数：8

共 25 条

[1]

[Anonymous], PRACT DIAB INT, DOI DOI 10.1002/PDI.1522

[2] Further Improvement in Postprandial Glucose Control With Addition of Exenatide or Sitagliptin to Combination Therapy With Insulin Glargine and Metformin A proof-of-concept study [J].

Arnolds, Sabine ;

Dellweg, Sibylle ;

Clair, Janina ;

Dain, Marie-Paule ;

Nauck, Michael A. ;

Rave, Klaus ;

Kapitza, Christoph .

DIABETES CARE, 2010, 33 (07) :1509-1515

[3] Use of Twice-Daily Exenatide in Basal Insulin-Treated Patients With Type 2 Diabetes A Randomized, Controlled Trial [J].

Buse, John B. ;

Bergenstal, Richard M. ;

Glass, Leonard C. ;

Heilmann, Cory R. ;

Lewis, Michelle S. ;

Kwan, Anita Y. M. ;

Hoogwerf, Byron J. ;

Rosenstock, Julio .

ANNALS OF INTERNAL MEDICINE, 2011, 154 (02) :103-+

[4] Sequential Intensification of Metformin Treatment in Type 2 Diabetes With Liraglutide Followed by Randomized Addition of Basal Insulin Prompted by A1C Targets [J].

DeVries, J. Hans ;

Bain, Stephen C. ;

Rodbard, Helena W. ;

Seufert, Jochen ;

D'Alessio, David ;

Thomsen, Anne B. ;

Zychma, Marcin ;

Rosenstock, Julio .

DIABETES CARE, 2012, 35 (07) :1446-1454

[5] Sustained beneficial metabolic effects 18 months after a 30-day very low calorie diet in severely obese, insulin-treated patients with type 2 diabetes [J].

Jazet, Ingrid M. ;

de Craen, Anton J. ;

van Schie, Eveline M. ;

Meinders, A. Edo .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 77 (01) :70-76

[6] Four Weeks of Treatment With Liraglutide Reduces Insulin Dose Without Loss of Glycemic Control in Type 1 Diabetic Patients With and Without Residual β-Cell Function [J].

Kielgast, Urd ;

Krarup, Thure ;

Holst, Jens Juul ;

Madsbad, Sten .

DIABETES CARE, 2011, 34 (07) :1463-1468

[7] Synthetic exendin-4 (Exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes [J].

Kolterman, OG ;

Buse, JB ;

Fineman, MS ;

Gaines, E ;

Heintz, S ;

Bicsak, TA ;

Taylor, K ;

Kim, D ;

Aisporna, M ;

Wang, Y ;

Baron, AD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (07) :3082-3089

[8] The Effect of Liraglutide Added to U-500 Insulin in Patients with Type 2 Diabetes and High Insulin Requirements [J].

Lane, Wendy ;

Weinrib, Stephen ;

Rappaport, Jonathan .

DIABETES TECHNOLOGY & THERAPEUTICS, 2011, 13 (05) :592-595

[9] Combination therapy with insulin glargine and exenatide: real-world outcomes in patients with type 2 diabetes [J].

Levin, Philip ;

Wei, Wenhui ;

Wang, Li ;

Pan, Chunshen ;

Douglas, Damon ;

Baser, Onur .

CURRENT MEDICAL RESEARCH AND OPINION, 2012, 28 (03) :439-446

[10] CLINICAL OUTCOMES USING LONG-TERM COMBINATION THERAPY WITH INSULIN GLARGINE AND EXENATIDE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS [J].

Levin, Philip A. ;

Mersey, James H. ;

Zhou, Steven ;

Bromberger, Lee A. .

ENDOCRINE PRACTICE, 2012, 18 (01) :17-25

← 1 2 3 →