Isolation and characterization of human epidermal stem cells

被引：29
|
作者：
Jones, PH
机构：
来源：
CLINICAL SCIENCE | 1996年 / 91卷 / 02期
关键词：
cell adhesion; cell differentiation; cell division; integrins; keratinocytes;
D O I：
10.1042/cs0910141
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
1. The keratinocytes in human epidermis are constantly turned over and replaced by a population of stem cells located in the basal epidermal layer. Until recently there were no markers allowing the isolation of viable epidermal stem cells, However, it has now been shown that epidermal stem cells can be isolated both in vitro and direct from the epidermis as they express high levels of functional beta(1) integrin family receptors for extracellular matrix proteins. 2. The evidence for integrins as stem cell markers and the insights that have been gained into stem cell behaviour are reviewed.
引用
收藏
页码：141 / 146
页数：6
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