Desorption ionization of biomolecules on metals

被引：30
|
作者：
Hsu, Nien-Feen [2 ]
Tseng, Susan Yu [1 ]
Wu, Chung-Yi [1 ]
Ren, Chien-Tai [1 ]
Lee, Yuan-Chang [1 ]
Wong, Chi-Huey [1 ,2 ]
Chen, Chung-Hsuan [1 ,2 ]
机构：
[1] Acad Sinica, Genom Res Ctr, Taipei, Taiwan
[2] Natl Taiwan Univ, Dept Chem & Biol Chem, Taipei 10764, Taiwan
来源：
ANALYTICAL CHEMISTRY | 2008年 / 80卷 / 13期
关键词：
D O I：
10.1021/ac800435r
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Direct desorption ionization of various types of biomolecules on metal substrates without the need of matrices was observed by a time-of-flight mass spectrometer. It provides a new convenient method for detection of small biomolecules without the confusion of ion peaks from matrix compounds. Simple commercial Al foil can be used as the substrate to obtain mass spectra of biomolecules without the need of an etching process to produce a porous surface such as with direct ionization on silicon (DIOS). The desorption and ionization mechanism is also discussed.
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页码：5203 / 5210
页数：8
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