Spread of drug-resistant Streptococcus pneumoniae in Asian countries:: Asian Network for Surveillance of Resistant Pathogens (ANSORP) study

被引:196
作者
Song, JH
Lee, NY
Ichiyama, S
Yoshida, R
Hirakata, Y
Fu, W
Chongthaleong, A
Aswapokee, N
Chiu, CH
Lalitha, MK
Thomas, K
Perera, J
Yee, TT
Jamal, F
Warsa, UC
Vinh, BX
Jacobs, MR
Appelbaum, PC
Pai, CH
机构
[1] Sungkyunkwan Univ, Sch Med, Div Infect Dis, Samsung Med Ctr,Dept Med,Kangnam Ku, Seoul 135710, South Korea
[2] Asan Med Ctr, Seoul, South Korea
[3] Nagoya Univ, Nagoya, Aichi, Japan
[4] Nagasaki Univ, Nagasaki 852, Japan
[5] Shanghai Med Univ, Shanghai 200032, Peoples R China
[6] Chulalongkorn Univ, Bangkok 10330, Thailand
[7] Siriraj Hosp, Bangkok, Thailand
[8] Chang Gung Childrens Hosp, Taipei, Taiwan
[9] Christian Med Coll & Hosp, Vellore 632004, Tamil Nadu, India
[10] Univ Colombo, Colombo, Sri Lanka
[11] Natl Univ Singapore, Singapore 117548, Singapore
[12] Univ Kebangsaan Malaysia, Kuala Lumpur, Malaysia
[13] Univ Indonesia, Jakarta, Indonesia
[14] Nhi Dong 2 Childrens Hosp, Ho Chi Minh City, Vietnam
[15] Case Western Reserve Univ, Cleveland, OH 44106 USA
[16] Milton S Hershey Med Ctr, Hershey, PA 17033 USA
关键词
D O I
10.1086/514783
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antimicrobial susceptibility of 996 isolates of Streptococcus pneumoniae from clinical specimens was investigated in II Asian countries from September 1996 to June 1997. Korea had the greatest frequency of nonsusceptible strains to penicillin with 79.7%, followed by Japan (65.3%), Vietnam (60.8%), Thailand (57.9%), Sri Lanka (41.2%), Taiwan (38.7%), Singapore (23.1%), Indonesia (21.0%), China (9.8%), Malaysia (9.0%), and India (3.8%). Serotypes 23F and 19F were the most common. Pulsed-field gel electrophoresis (PFGE) of 154 isolates from Asian countries showed several major PFGE patterns. The serotype 23F Spanish clone shared the same PFGE pattern with strains from Korea, Japan, Singapore, Taiwan, Thailand, and Malaysia. Fingerprinting analysis of pbp1a, pbp2x, and pbp2b genes of 12 strains from six countries also showed identical fingerprints of penicillin-binding protein genes in most strains. These data suggest the possible introduction and spread of international epidemic clones into Asian countries and the increasing problems of pneumococcal drug resistance in Asian countries for the first time.
引用
收藏
页码:1206 / 1211
页数:6
相关论文
共 32 条
  • [1] ANTIMICROBIAL RESISTANCE IN STREPTOCOCCUS-PNEUMONIAE - AN OVERVIEW
    APPELBAUM, PC
    [J]. CLINICAL INFECTIOUS DISEASES, 1992, 15 (01) : 77 - 83
  • [2] AUSTRIAN R, 1981, REV INFECT DIS, V3, P183
  • [3] Evolving clinical problems with Streptococcus pneumoniae:: Increasing resistance to antimicrobial agents, and failure of traditional optochin identification in Chicago, Illinois, between 1993 and 1996
    Borek, AP
    Dressel, DC
    Hussong, J
    Peterson, LR
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1997, 29 (04) : 209 - 214
  • [4] CAPSULAR TYPES AND ANTIMICROBIAL RESISTANCE OF STREPTOCOCCUS-PNEUMONIAE ISOLATED IN KOREA
    CHONG, Y
    LEE, K
    KWON, OH
    HENRICHSEN, J
    [J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1995, 14 (06) : 528 - 531
  • [5] FENOLL A, 1991, REV INFECT DIS, V13, P56
  • [6] FRIEDLAND IR, 1994, NEW ENGL J MED, V331, P377, DOI 10.1056/NEJM199408113310607
  • [7] HANSMAN D, 1967, LANCET, V2, P264
  • [8] THE PREVALENCE OF DRUG-RESISTANT STREPTOCOCCUS-PNEUMONIAE IN ATLANTA
    HOFMANN, J
    CETRON, M
    FARLEY, MM
    BAUGHMAN, WS
    FACKLAM, RR
    ELLIOTT, JA
    DEAVER, KA
    BREIMAN, RF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (08) : 481 - 486
  • [9] EMERGENCE OF MULTIPLY RESISTANT PNEUMOCOCCI
    JACOBS, MR
    KOORNHOF, HJ
    ROBINSBROWNE, RM
    STEVENSON, CM
    VERMAAK, ZA
    FREIMAN, I
    MILLER, GB
    WITCOMB, MA
    ISAACSON, M
    WARD, JI
    AUSTRIAN, R
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1978, 299 (14) : 735 - 740
  • [10] MOLECULAR EPIDEMIOLOGY OF PENICILLIN-RESISTANT PNEUMOCOCCI ISOLATED IN NAIROBI, KENYA
    KELL, CM
    JORDENS, JZ
    DANIELS, M
    COFFEY, TJ
    BATES, J
    PAUL, J
    GILKS, C
    SPRATT, BG
    [J]. INFECTION AND IMMUNITY, 1993, 61 (10) : 4382 - 4391