Small molecule AX-024 targets T cell receptor signaling by disrupting CD3ε-Nck interaction

被引：5

作者：

Alarcon, Balbino ^{[1
]}

Borroto, Aldo ^{[1
]}

机构：

[1] CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2020年 / 295卷 / 29期

关键词：

D O I：

10.1074/jbc.L120.014338

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：10076 / 10076

页数：1

共 4 条

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[3] Small molecule AX-024 reduces T cell proliferation independently of CD3?/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain [J].

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