HIV co-infection in HTLV-1 carriers in Spain

被引：17

作者：

de Mendoza, Carmen ^{[1
,2
,3
]}

Caballero, Estrella ^{[4
]}

Aguilera, Antonio ^{[5
]}

Benito, Rafael ^{[6
]}

Macia, Dolores ^{[7
]}

Garcia-Costa, Juan ^{[8
]}

Soriano, Vicente ^{[9
]}

Rodriguez, C. ^{[10
]}

Vera, M. ^{[10
]}

del Romero, J. ^{[10
]}

Marcaida, G. ^{[11
]}

Ocete, M. D. ^{[11
]}

Caballero, E. ^{[12
]}

Molina, I ^{[12
]}

Aguilera, A. ^{[13
]}

Rodriguez-Calvino, J. J. ^{[13
]}

Navarro, D. ^{[13
]}

Rivero, C. ^{[13
]}

Vilarino, M. D. ^{[13
]}

Benito, R. ^{[14
]}

Algarate, S. ^{[14
]}

Gil, J. ^{[14
]}

Ortiz de Lejarazu, R. ^{[15
]}

Rojo, S. ^{[15
]}

Eiros, J. M. ^{[16
]}

San Miguel, A. ^{[16
]}

Manzardo, C. ^{[17
]}

Miro, J. M. ^{[17
]}

Garcia, J. ^{[18
]}

Paz, I ^{[18
]}

Poveda, E. ^{[19
]}

Calderon, E. ^{[20
,21
]}

Escudero, D. ^{[22
]}

Trigo, M. ^{[23
]}

Diz, J. ^{[23
]}

Garcia-Campello, M. ^{[23
]}

Rodriguez-Iglesias, M. ^{[24
]}

Hernandez-Betancor, A. ^{[25
]}

Martin, A. M. ^{[25
]}

Ramos, J. M. ^{[26
]}

Gimeno, A. ^{[26
]}

Gutierrez, F. ^{[27
]}

Rodriguez, J. C. ^{[27
]}

Sanchez, V ^{[27
]}

Gomez-Hernando, C. ^{[28
]}

Cilla, G. ^{[29
]}

Perez-Trallero, E. ^{[29
]}

Lopez-Aldeguer, J. ^{[30
]}

Fernandez-Pereira, L. ^{[31
]}

Niubo, J. ^{[32
]}

机构：

[1] Puerta de Hierro Res Inst, Madrid, Spain

[2] Univ Hosp, Madrid, Spain

[3] CEU San Pablo Univ, Microbiol Dept, Madrid, Spain

[4] Hosp Valle De Hebron, Barcelona, Spain

[5] Complexo Hosp Univ, Santiago, Spain

[6] Hosp Clin Lozano Blesa, Zaragoza, Spain

[7] Hosp Son Llatzer, Mallorca, Spain

[8] Complejo Hosp Univ, Orense, Spain

[9] UNIR Hlth Sci Sch & Med Ctr, Madrid, Spain

[10] Ctr Sanitario Sandoval, Madrid, Spain

[11] Hosp Gen Univ, Valencia, Spain

[12] Hosp Vall dHebro, Barcelona, Spain

[13] Hosp Conxo CHUS, Santiago, Chile

[14] Hosp Clin Univ Lozano Blesa, Zaragoza, Spain

[15] Hosp Clin Univ, Valladolid, Spain

[16] Hosp Rio Hortega, Valladolid, Spain

[17] Hosp Clin IDIBAPS, Barcelona, Spain

[18] Hosp Cristal Pinor, Orense, Spain

[19] INIBIC Complejo Hosp Univ, La Coruna, Spain

[20] Hosp Virgen del Rocio, Seville, Spain

[21] CIBERESP, Seville, Spain

[22] Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

[23] Complejo Hosp, Pontevedra, Spain

[24] Hosp Univ, Puerto Real, Spain

[25] Hosp Insular Hosp Univ, Las Palmas Gran Canaria, Spain

[26] Hosp Univ, Alicante, Spain

[27] Hosp Gen, Elche, Spain

[28] Complejo Hosp Virgen de la Salud, Toledo, Spain

[29] Hosp Donostia, San Sebastian, Spain

[30] Hosp La Fe, Valencia, Spain

[31] Hosp San Pedro de Alcantara, Caceres, Spain

[32] Ciudad Sanitaria Bellvitge, Barcelona, Spain

[33] Hosp Univ La Laguna, Tenerife, Spain

[34] Hosp Gen, Mataro, Spain

[35] Hosp Son Llatzer, Palma De Mallorca, Spain

[36] Hosp Meixoeiro, Vigo, Spain

[37] Hosp Bierzo, Ponferrada, Spain

[38] Hosp Basurto, Bilbao, Spain

[39] Hosp Cruces, Bilbao, Spain

[40] Hosp Miguel Servet, Zaragoza, Spain

[41] Hosp Virgen de la Victoria, Malaga, Spain

[42] Hosp Poniente, Almeria, Spain

[43] Hosp Univ, Getafe, Spain

[44] Fdn Jimenez Diaz, Madrid, Spain

[45] Hosp Gregorio Maranon, Madrid, Spain

[46] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[47] ICS, Barcelona, Spain

[48] Complejo Hosp Navarra, Pamplona, Spain

[49] Banco Sangre & Tejidos, Barcelona, Spain

[50] Ctr Transfus, Madrid, Spain

来源：

VIRUS RESEARCH | 2019年 / 266卷

关键词：

HTLV; HIV; Co-infection; AIDS; Tropical spastic paraparesis; Adult T-cell leukemia; Epidemiology; Antiretroviral therapy; Late diagnosis; VIRUS TYPE-1 INFECTION; IMPACT;

D O I：

10.1016/j.virusres.2019.04.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain. Methods: A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection. Results: Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia). HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection. Conclusion: HIV coinfection is infrequent (< 5%) among HTLV-1 carriers in Spain. More than half of co-infected patients come from Latin America. Sexual contact is the most frequent risk behavior, being MSM one third of cases. Late diagnosis explains the high rate (9/12) of clinical manifestations in our HIV-HTLV co-infected population.

引用

页码：48 / 51

页数：4

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