The diallelic locus encoding the minor histocompatibility antigen HA-1 is evolutionarily conserved

被引：2
作者：
Wieles, B
Pool, J
Wilke, M
Weber, M
Kolb, HJ
Bontrop, RE
Goulmy, E
机构：
[1] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2333 ZA Leiden, Netherlands
[2] Erasmus Med Ctr, Dept Biochem, Rotterdam, Netherlands
[3] Klinikum Univ Munich Grosshadern, Dept Med 111, Munich, Germany
[4] Biomed Primate Res Ctr, Dept Comparat Genet & Refinement, Rijswijk, Netherlands
来源：
TISSUE ANTIGENS | 2006年 / 68卷 / 01期
关键词：
evolution; minor histocompatibility antigen HA-1; single nucleotide polymorphism; T cell epitope;
D O I：
10.1111/j.1399-0039.2006.00603.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The polymorphic minor histocompatibility antigen HA-1 induces powerful T-cell alloreactivities with important consequences for graft-vs-tumor activity and development of graft-vs-host disease in patients after human leukocyte antigen-matched stem-cell transplantation (SCT). In view of possible translational animal studies, we analyzed the evolutionary conservation of the diallelic HA-1 locus in four mammalian species. Our results show that rodents do not encode the HA-1(H) allele, neither show polymorphism in this position on the HA-1 gene. Contrariwise, the HA-1(H) allele is present in non-human primate species and dogs. Interestingly, both the HA-1(H) T-cell epitope and its non-immunogenic counterpart HA-1(R) are present in the latter species. Thus, the HA-1 allelic polymorphism is conserved in evolution in primates and dogs.
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收藏
页码：62 / 65
页数：4
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