Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone

被引：53

作者：

Ben Zakour, Nouri L. ^{[1
]}

Davies, Mark R. ^{[1
,2
]}

You, Yuanhai ^{[3
,4
]}

Chen, Jonathan H. K. ^{[5
,6
,7
]}

Forde, Brian M. ^{[1
]}

Stanton-Cook, Mitchell ^{[1
]}

Yang, Ruifu ^{[8
]}

Cui, Yujun ^{[8
]}

Barnett, Timothy C. ^{[1
]}

Venturini, Carola ^{[1
]}

Ong, Cheryl-Iynn Y. ^{[1
]}

Tse, Herman ^{[5
,6
,7
]}

Dougan, Gordon ^{[2
]}

Zhang, Jianzhong ^{[3
,4
]}

Yuen, Kwok-Yung ^{[5
,6
,7
]}

Beatson, Scott A. ^{[1
]}

Walker, Mark J. ^{[1
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, Australian Infect Dis Res Ctr, Brisbane, Qld 4072, Australia

[2] Wellcome Trust Sanger Inst, Cambridge, England

[3] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China

[4] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China

[5] Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China

[6] Univ Hong Kong, Res Ctr Infect & Immunol, Hong Kong, Hong Kong, Peoples R China

[7] Univ Hong Kong, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China

[8] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

英国医学研究理事会; 英国惠康基金; 澳大利亚研究理事会;

关键词：

PUBLIC-HEALTH; HONG-KONG; PYOGENES; EPIDEMIC; DISEASE; EVOLUTION;

D O I：

10.1038/srep15877

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The group A Streptococcus (GAS) M1T1 clone emerged in the 1980s as a leading cause of epidemic invasive infections worldwide, including necrotizing fasciitis and toxic shock syndrome(1-3). Horizontal transfer of mobile genetic elements has played a central role in the evolution of the M1T1 clone(4-5), with bacteriophage-encoded determinants DNase Sda1(6) and superantigen SpeA2(7) contributing to enhanced virulence and colonization respectively. Outbreaks of scarlet fever in Hong Kong and China in 2011, caused primarily by emm12 GAS(8-10), led to our investigation of the next most common cause of scarlet fever, emm1 GAS(8,9). Genomic analysis of 18 emm1 isolates from Hong Kong and 16 emm1 isolates from mainland China revealed the presence of mobile genetic elements associated with the expansion of emm12 scarlet fever clones(10,11) in the M1T1 genomic background. These mobile genetic elements confer expression of superantigens SSA and SpeC, and resistance to tetracycline, erythromycin and clindamycin. Horizontal transfer of mobile DNA conferring multi-drug resistance and expression of a new superantigen repertoire in the M1T1 clone should trigger heightened public health awareness for the global dissemination of these genetic elements.

引用

页数：7

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