Anticancer, Azonafide-Inspired Fluorescent Ligands and Their Rhenium(I) Complexes for Cellular Imaging

被引：15

作者：

Langdon-Jones, Emily E. ^{[1
]}

Jones, Ariana B. ^{[1
]}

Williams, Catrin F. ^{[2
,3
]}

Hayes, Anthony J. ^{[3
]}

Lloyd, David ^{[3
]}

Mottram, Huw J. ^{[4
]}

Pope, Simon J. A. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, S Glam, Wales

[2] Cardiff Univ, Sch Engn, Cardiff CF24 3AA, S Glam, Wales

[3] Cardiff Univ, Sch Biosci, Cardiff CF10 3AT, S Glam, Wales

[4] Cardiff Univ, Sch Pharm, Cardiff CF10 3NB, S Glam, Wales

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2017年 / 03期

关键词：

Fluorescence; Cell imaging; Rhenium; Azonafide; N ligands; Cancer; ANTITUMOR-ACTIVITY; IN-VITRO; AGENTS; DNA; CHEMISTRY; AMONAFIDE; THERAPY; LOCALIZATION; DERIVATIVES; MICROSCOPY;

D O I：

10.1002/ejic.201601271

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two dipicolyamino-conjugated anthracene-1,9-dicarboximide fluorophores and their corresponding Re-I complexes have been synthesised and photophysically examined. All species were fluorescent in the visible region at about 490 nm with lifetimes up to 16 ns. The anticancer potency of the ligands and complexes was demonstrated across a range of cancer cell lines (LOVO, PC3, A549, MCF-7). Cell imaging studies with MCF7 cells and Schizosaccharomyces pombe show that these fluorophores exhibit variable intracellular localisation patterns that are structure-dependent.

引用

页码：759 / 766

页数：8

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