The E5 proteins

被引：199

作者：

DiMaio, Daniel ^{[1
,2
,3
]}

Petti, Lisa M. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Genet, POB 208005, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

VIROLOGY | 2013年 / 445卷 / 1-2期

关键词：

Papillomaviruses; Cervical cancer; Transmembrane proteins; PDGF receptor; Vacuolar ATPase; EGF receptor; HPV; HUMAN-PAPILLOMAVIRUS TYPE-16; GROWTH-FACTOR RECEPTOR; FACTOR-BETA RECEPTOR; MHC CLASS-I; VACUOLAR H+-ATPASE; OPEN READING FRAME; HUMAN FORESKIN KERATINOCYTES; MORTAL HUMAN FIBROBLASTS; FASL-MEDIATED APOPTOSIS; CELL-CYCLE PROGRESSION;

D O I：

10.1016/j.virol.2013.05.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The E5 proteins are short transmembrane proteins encoded by many animal and human papillomaviruses. These proteins display transforming activity in cultured cells and animals, and they presumably also play a role in the productive virus life cycle. The E5 proteins are thought to act by modulating the activity of cellular proteins. Here, we describe the biological activities of the best-studied E5 proteins and discuss the evidence implicating specific protein targets and pathways in mediating these activities. The primary target of the 44-amino acid BPV1 E5 protein is the PDGF beta receptor, whereas the EGF receptor appears to be an important target of the 83-amino acid HPV16 E5 protein. Both E5 proteins also bind to the vacuolar ATPase and affect MHC class I expression and cell-cell communication. Continued studies of the E5 proteins will elucidate important aspects of transmembrane protein- protein interactions, cellular signal transduction, cell biology, virus replication, and tumorigenesis. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：99 / 114

页数：16

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