A new benzophenone with biological activities purified from Aspergillus fumigatus SWZ01

被引：12

作者：

Liu, Bing ^{[1
,2
,3
]}

Chen, Ning ^{[2
,4
]}

Chen, Ying-xiang ^{[1
,4
]}

Shen, Jie-jing ^{[4
]}

Xu, Ying ^{[2
,4
]}

Ji, Yu-bin ^{[1
,4
]}

机构：

[1] Harbin Univ Commerce, Pharmaceut Engn Technol Res Ctr, Harbin, Peoples R China

[2] Harbin Univ Commerce, Postdoctoral Ctr Chinese Pharm, Harbin, Peoples R China

[3] Harbin Univ Commerce, Inst Pharmacol, Postdoctoral Workstn, Harbin, Peoples R China

[4] Natl Ctr Anticanc Nat Med Engn, Harbin, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 24期

关键词：

Benzophenone; antioxidant activity; alpha-glucosidase inhibitory activity; ANTIOXIDANT; DERIVATIVES;

D O I：

10.1080/14786419.2020.1825427

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Strain SZW01 was isolated from sea sediment collected from Shenzhen in Guangdong province, China, and was later identified asAspergillus fumigatusby16S rDNA sequence analysis. Various chromatographic processes led to the isolation and purification of three compounds from the fermentation culture of SZW01, including a new compound, 2,6'-dihydroxy-2,4'dimethoxy-8'-methyl-6-methoxy-acyl-ethyl-diphenylmethanone (1), and two known compounds: fumigaclavine C (2) and alternarosin A (3), as characterised by UV, IR, 1 D, 2 D-NMR and MS data. The antioxidant and alpha-glucosidase inhibitory activities of these compounds were evaluated. The result illustrated that compound1exhibited a moderate antioxidant activity and stronger alpha-glucosidase inhibitory activity than acarbose. [GRAPHICS] .

引用

页码：5710 / 5719

页数：10

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