Antischistosomal and Cytotoxic Effects of the Essential Oil of Tetradenia riparia (Lamiaceae)

被引：0
作者：
de Melo, Nathalya I. [1 ]
Mantovani, Andre L. L. [1 ]
de Oliveira, Pollyanna F. [1 ]
Groppo, Milton [2 ]
da Silva Filho, Ademar A. [3 ]
Rodrigues, Vanderlei [4 ]
Cunha, Wilson R. [1 ]
Tavares, Denise C. [1 ]
Magalhaes, Lizandra G. [1 ]
Crotti, Antonio E. M. [1 ,2 ]
机构：
[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas, BR-14404600 Franca, SP, Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil
[3] Univ Fed Juiz de Fora, Fac Farm & Bioquim, BR-36036900 Juiz De Fora, MG, Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040900 Ribeirao Preto, SP, Brazil
来源：
NATURAL PRODUCT COMMUNICATIONS | 2015年 / 10卷 / 09期
基金：
瑞典研究理事会; 巴西圣保罗研究基金会;
关键词：
Cytotoxicity; Schistosoma mansoni; Essential oil; Tetradenia riparia; VITRO SCHISTOSOMICIDAL ACTIVITY; IN-VITRO; CHEMICAL-COMPOSITION; MANSONI; BRAZIL; PLANTS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This paper reports on the antischistosomal and cytotoxic effects of the essential oil obtained from Tetradenia riparia leaves (TR-EO). At concentrations of 50 and 100 mu g/mL, TR-EO killed all the worms after 120 and 24 h of incubation, respectively. At a concentration equal to or higher than 50 mu g/mL, this oil also separated the coupled pairs and decreased the adult worm motor activity after incubation periods higher than 72 h. In addition, at 120 h of incubation, TR-EO slightly decreased the number of eggs produced by Schistosoma mansoni adult worms and significantly reduced the percentage of developed eggs, in a dose-dependent manner. XTT-colorimetric assays showed that the tested TR-EO concentrations were not considerably cytotoxic to V79 cells (IC50 = 253.5 mu g/mL). The effects of TR-EO on egg development were noteworthy; therefore, this essential oil deserves further investigation to identify the chemical constituents that elicit activity against S. mansoni.
引用
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页码：1627 / 1630
页数：4
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