Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents

被引：34
作者：
Rizk, Ola H. [1 ]
Shaaban, Omaima G. [1 ]
El-Ashmawy, Ibrahim M. [2 ]
机构：
[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt
[2] Univ Alexandria, Fac Vet Med, Dept Pharmacol, Alexandria 21521, Egypt
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷
关键词：
Synthesis; Thienopyrimidines; Fused thienopyrimidines; Anti-inflammatory activity; ANTIBACTERIAL ACTIVITIES; DERIVATIVES; QUINAZOLIN-4-(3H)-ONES; INHIBITORS;
D O I：
10.1016/j.ejmech.2012.07.007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium. (C) 2012 Elsevier Masson SAS. All rights reserved.
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页码：85 / 93
页数：9
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