DNA double-strand break repair from head to tail

被引：124

作者：

Hopfner, KP

Putnam, CD

Tainer, JA

机构：

[1] Univ Munich, Gene Ctr, Munich, Germany

[2] Ludwig Inst Canc Res, San Diego, CA USA

[3] Scripps Res Inst, La Jolla, CA USA

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(02)00297-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA double-strand break repair is a complex process that requires multiple enzymatic and structural activities to rejoin or repair the broken DNA ends using one of several repair pathways. These enzymatic and structural activities include end detection, end processing and alignment of DNA ends. Recent structural and functional studies of the DNA double-strand break repair factors Mre11/Rad50, Ku70/80 and Xrcc4 show how these enzymes combine and assemble both enzymatic and structural activities in DNA double-strand break repair.

引用

页码：115 / 122

页数：8

共 67 条

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