Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities

被引：102

作者：

Ming, Guo-li ^{[1
,2
,3
,4
]}

Tang, Hengli ^{[5
]}

Song, Hongjun ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[5] Florida State Univ, Dept Biol Sci, B-157, Tallahassee, FL 32306 USA

来源：

CELL STEM CELL | 2016年 / 19卷 / 06期

关键词：

BORNE ENCEPHALITIS-VIRUS; NEURAL CREST CELLS; BINDING KINASE 1; DENGUE VIRUS; CEREBRAL ORGANOIDS; ENDOTHELIAL-CELLS; INFECTION; RNA; BRAIN; ACTIVATION;

D O I：

10.1016/j.stem.2016.11.014

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The re-emergence of Zika virus (ZIKV) and its suspected link with various disorders in newborns and adults led the World Health Organization to declare a global health emergency. In response, the stem cell field quickly established platforms for modeling ZIKV exposure using human pluripotent stem cell-derived neural progenitors and brain organoids, fetal tissues, and animal models. These efforts provided significant insight into cellular targets, pathogenesis, and underlying biological mechanisms of ZIKV infection as well as platforms for drug testing. Here we review the remarkable progress in stem cell-based ZIKV research and discuss current challenges and future opportunities.

引用

页码：690 / 702

页数：13

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