Diagnosis of acquired aplastic anemia

被引：38

作者：

Rovo, A. ^{[1
]}

Tichelli, A. ^{[1
]}

Dufour, C. ^{[2
]}

机构：

[1] Univ Basel Hosp, Dept Hematol, CH-4031 Basel, Switzerland

[2] G Gaslini Childrens Hosp, Dept Hematol, Genoa, Italy

来源：

BONE MARROW TRANSPLANTATION | 2013年 / 48卷 / 02期

关键词：

PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; BONE-MARROW-TRANSPLANTATION; IMMUNOSUPPRESSIVE THERAPY; MYELODYSPLASTIC SYNDROME; PREDICTING RESPONSE; DISEASES; EPIDEMIOLOGY; ASSOCIATION; COINCIDENCE; DISORDERS;

D O I：

10.1038/bmt.2012.230

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Since the introduction of the concept of aplastic anemia (AA) by Paul Ehrlich in 1888 and despite the current better understanding of the underlying mechanisms involved in this disease, a clear delimitation among BM failure syndromes is still a matter of debate. The diagnosis of AA can be difficult basically due to the overlapping morphological characteristics with other BM failure disorders. This paper reviews critical data relevant to the diagnosis of acquired AA and recommends work out steps and main considerations to determine severity and characterization of the disease. The diagnostic challenge in the differentiation between AA and hypoplastic myelodysplastic syndromes is also addressed. The definition of the response criteria to treatment belongs to the diagnostic tasks and it is included in this review as well as an overview of novel tools for the diagnosis of AA. Bone Marrow Transplantation (2013) 48, 162-167; doi:10.1038/bmt.2012.230; published online 19 November 2012

引用

页码：162 / 167

页数：6

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