Synthesis of methyl sulfomycinate, sulfomycinic amide and sulfomycinine, degradation products of the sulfomycin thiopeptide antibiotics

被引：10

作者：

Bagley, MC ^{[1
]}

Glover, C ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, Wales

来源：

TETRAHEDRON | 2006年 / 62卷 / 01期

关键词：

sulfomycin; thiopeptide antibiotics; chemical degradation; thiazoles;

D O I：

10.1016/j.tet.2005.09.134

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The convergent synthesis of methyl sulfomycinate and sulfomycinic amide, two acidic methanolysis products of the sulfomycin thiopeptide antibiotics, is achieved starting from diethoxyacetonitrile. Further confirmation of structure is obtained by beating methyl sulfomycinate at 110 degrees C in hydrochloric acid to give (+/-)-sulfomycinine hydrochloride, the acid hydrolysate of sulfornycin I. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：66 / 72

页数：7

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[2]

ABE H, 1977, TETRAHEDRON LETT, P735

[3]

ABE H, 1978, TETRAHEDRON LETT, P2791

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