Positive affect dimensions and their association with inflammatory biomarkers in patients with chronic heart failure

被引：62

作者：

Brouwers, Corline ^{[1
]}

Mommersteeg, Paula M. C. ^{[1
]}

Nyklicek, Ivan ^{[1
]}

Pelle, Aline J. ^{[1
]}

Westerhuis, Bert L. W. J. J. M. ^{[3
]}

Szabo, Balazs M. ^{[2
]}

Denollet, Johan ^{[1
]}

机构：

[1] Tilburg Univ, Dept Med Psychol & Neuropsychol, CoRPS Ctr Res Psychol Somat Dis, NL-5000 LE Tilburg, Netherlands

[2] Elisabeth Hosp, Dept Cardiol, Tilburg, Netherlands

[3] Elisabeth Hosp, Clin Chem & Hematol Lab, Tilburg, Netherlands

来源：

BIOLOGICAL PSYCHOLOGY | 2013年 / 92卷 / 02期

关键词：

Positive affect; Inflammation; Heart failure; DEPRESSIVE SYMPTOMS; PROINFLAMMATORY CYTOKINES; EMOTIONAL STYLE; DISEASE; HEALTH; MOOD; REHABILITATION; NEUROENDOCRINE; RECEPTORS; MORTALITY;

D O I：

10.1016/j.biopsycho.2012.10.002

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Background: In cardiac patients positive affect has found to be associated with improved clinical outcomes, with reduced inflammation being one of the potential mechanisms responsible. Methods: Positive affect was assessed using The Global Mood Scale (GMS), Positive and Negative Affect Schedule (PANAS), and Hospital Anxiety and Depression Scale (HADS) in patient with chronic heart failure (N = 210; 67 +/- 9 years, 79% men). Markers of inflammation (TNF alpha, sTNFr1, 5TNFr2, IL-6 and CRP) were measured and averaged at three consecutive time points. Results: The positive affect dimensions of the GMS and PANAS were significantly associated with lower averaged levels of 5TNFr2, TNF alpha and IL-6 (p <.1), even after adjustment for clinical and lifestyle confounders. Positive affect of the HADS was significantly associated with lower averaged levels of hsCRP (p <.1), but was no longer significant after correction for lifestyle confounders and depressive symptoms. Conclusion: Positive affect is associated with reduced inflammation in patients with heart failure. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：220 / 226

页数：7

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