Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

被引：0
作者：
Petersen, E. J. [1 ]
Marquis, B. J. [1 ]
Jaruga, P. [1 ]
Dizdaroglu, M. [1 ]
Nelson, B. C. [1 ]
机构：
[1] NIST, Mat Measurement Lab, Div Biochem Sci, Gaithersburg, MD 20899 USA
来源：
NANOTECHNOLOGY 2012, VOL 3: BIO SENSORS, INSTRUMENTS, MEDICAL, ENVIRONMENT AND ENERGY | 2012年
关键词：
nanotoxicology; Comet assay; genotoxicity; biomarker; toxicology; NANOPARTICLES; EXPOSURE;
D O I：
暂无
中图分类号：
TE [石油、天然气工业]; TK [能源与动力工程];
学科分类号：
0807 ; 0820 ;
摘要：
Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage (DNA lesions) in living systems. The National Institute of Standards and Technology has established a comprehensive research program focused on identifying mechanisms of DNA damage caused by commercially relevant engineered nanoparticles (NPs) using these techniques for the quantification of oxidatively-induced DNA damage. We present an overview of our recent findings from studies on metal (gold) and metal oxide (ultrafine superparamagnetic iron oxide) nanoparticles using isotope dilution liquid chromatography and gas chromatography/mass spectrometry analysis, respectively.
引用
收藏
页码：307 / 310
页数：4
相关论文
共 11 条
  • [1] Copper Oxide Nanoparticle Mediated DNA Damage in Terrestrial Plant Models
    Atha, Donald H.
    Wang, Huanhua
    Petersen, Elijah J.
    Cleveland, Danielle
    Holbrook, R. David
    Jaruga, Pawel
    Dizdaroglu, Miral
    Xing, Baoshan
    Nelson, Bryant C.
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2012, 46 (03) : 1819 - 1827
  • [2] APPLICATION OF CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY TO CHEMICAL CHARACTERIZATION OF RADIATION-INDUCED BASE DAMAGE OF DNA - IMPLICATIONS FOR ASSESSING DNA-REPAIR PROCESSES
    DIZDAROGLU, M
    [J]. ANALYTICAL BIOCHEMISTRY, 1985, 144 (02) : 593 - 603
  • [3] POSSIBILITIES AND LIMITATIONS OF MODELING ENVIRONMENTAL EXPOSURE TO ENGINEERED NANOMATERIALS BY PROBABILISTIC MATERIAL FLOW ANALYSIS
    Gottschalk, Fadri
    Sonderer, Tobias
    Scholz, Roland W.
    Nowack, Bernd
    [J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2010, 29 (05) : 1036 - 1048
  • [4] Modeled Environmental Concentrations of Engineered Nanomaterials (TiO2, ZnO, Ag, CNT, Fullerenes) for Different Regions
    Gottschalk, Fadri
    Sonderer, Tobias
    Scholz, Roland W.
    Nowack, Bernd
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2009, 43 (24) : 9216 - 9222
  • [5] Measurement of formamidopyrimidines in DNA
    Jaruga, Pawel
    Kirkali, Guedal
    Dizdaroglu, Miral
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2008, 45 (12) : 1601 - 1609
  • [6] Biomarkers signal contaminant effects on the organs of English sole (Parophrys vetulus) from Puget Sound
    Malins, Donald C.
    Anderson, Katie M.
    Stegeman, John J.
    Jaruga, Pawel
    Green, Virginia M.
    Gilman, Naomi K.
    Dizdaroglu, Miral
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2006, 114 (06) : 823 - 829
  • [7] Exposure modeling of engineered nanoparticles in the environment
    Mueller, Nicole C.
    Nowack, Bernd
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (12) : 4447 - 4453
  • [8] Toxic potential of materials at the nanolevel
    Nel, A
    Xia, T
    Mädler, L
    Li, N
    [J]. SCIENCE, 2006, 311 (5761) : 622 - 627
  • [9] Nelson B. C., 2012, NANOTOXICOL IN PRESS
  • [10] Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA
    Petersen, Elijah J.
    Nelson, Bryant C.
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 398 (02) : 613 - 650
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