Cannabinoid mitigation of neuronal morphological change important to development and learning: Insight from a zebra finch model of psychopharmacology

被引：5

作者：

Soderstrom, Ken ^{[1
]}

Gilbert, Marcoita T. ^{[1
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Pharmacol & Toxicol, Greenville, NC 27834 USA

来源：

LIFE SCIENCES | 2013年 / 92卷 / 8-9期

关键词：

Dendrite; Spines; Arc; Caspase-3; Zenk; Egr-1; Learning; Cannabinoid; Neuronal morphology; Development; MESSENGER-RNA EXPRESSION; IMMEDIATE-EARLY GENE; COGNITIVE IMPAIRMENT; ADOLESCENT EXPOSURE; CB1; RECEPTORS; RAT-BRAIN; ARC/ARG3.1; MARIJUANA; GROWTH; THC;

D O I：

10.1016/j.lfs.2012.07.031

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Normal CNS development proceeds through late-postnatal stages of adolescent development. The activity-dependence of this development underscores the significance of CNS-active drug exposure prior to completion of brain maturation. Exogenous modulation of signaling important in regulating normal development is of particular concern. This mini-review presents a summary of the accumulated behavioral, physiological and biochemical evidence supporting such a key regulatory role for endocannabinoid signaling during late-postnatal CNS development. Our focus is on the data obtained using a unique zebra finch model of developmental psychopharmacology. This animal has allowed investigation of neuronal morphological effects essential to establishment and maintenance of neural circuitry, including processes related to synaptogenesis and dendritic spine dynamics. Altered neurophysiology that follows exogenous cannabinoid exposure during adolescent development has the potential to persistently alter cognition, learning and memory. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：467 / 475

页数：9

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