Effect of fruit extract on renal stone formation and kidney injury in rats

被引：7

作者：

Partovi, Nasrin ^{[1
]}

Ebadzadeh, Mohammad Reza ^{[2
]}

Fatemi, S. Jamilaldin ^{[1
]}

Khaksari, Mohammad ^{[3
]}

机构：

[1] Shahid Bahonar Univ Kerman, Dept Chem, Kerman, Iran

[2] Kerman Univ Med Sci, Dept Urol, Kerman, Iran

[3] Kerman Univ Med Sci, Dept Physiol, Kerman, Iran

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 10期

关键词：

Cactus fruit; calcium oxalate; MDA; SOD; OPUNTIA-FICUS-INDICA; CHEMICAL-CHARACTERIZATION;

D O I：

10.1080/14786419.2017.1320790

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This study investigated the effect of oral administration of Cactus fruit extracts on calcium oxalate deposition, malondialdehyde (MDA) and superoxide dismutase (SOD) activity in rat model. About 42 rats were used for the study. The animals were divided into seven groups. Control group maintained on regular rat food and drinking water throughout the study period, whereas in other groups nephrolithiasis was induced by ethylene glycol. Rats in kidney stone group were sacrificed after 28days and all remaining groups after 58days. Treatment groups were treated with 1 and 100mg/kg of aqueous and ethanolic extracts of Cactus fruit for 30days. After treatment, SOD activity was increased and MDA was decreased significantly. CaOx depositions were decreased significantly, especially in ethanolic extract of Cactus fruit in high dose (100mg/kg). [GRAPHICS] .

引用

页码：1180 / 1183

页数：4

共 13 条

[1]

Ali RFM, 2015, BIOCH ANAL BIOCH, V3, P1

[2] Free radicals and oxidative stress [J].

Andreoli, TE .

AMERICAN JOURNAL OF MEDICINE, 2000, 108 (08) :650-651

[3] Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) Mill. fruit juice:: Antioxidant and antiulcerogenic activity [J].

Galati, EM ;

Mondello, MR ;

Giuffrida, D ;

Dugo, G ;

Miceli, N ;

Pergolizzi, S ;

Taviano, MF .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (17) :4903-4908

[4]

Johnston BA., 1997, Herbalgram, V40, P49

[5] The antibacterial mechanism of berberine against Actinobacillus pleuropneumoniae [J].

Kang, Shuai ;

Li, Zhengwen ;

Yin, Zhongqiong ;

Jia, Renyong ;

Song, Xu ;

Li, Li ;

Chen, Zhenzhen ;

Peng, Lianci ;

Qu, Jing ;

Hu, Zhiqiang ;

Lai, Xin ;

Wang, Guangxi ;

Liang, Xiaoxia ;

He, Changliang ;

Yin, Lizi .

NATURAL PRODUCT RESEARCH, 2015, 29 (23) :2203-2206

[6]

Ketter K, 1991, J ETHNOPHARMACOL, V32, P225

[7] Hyperoxaluria-induced oxidative stress and antioxidants for renal protection [J].

Khan, SR .

UROLOGICAL RESEARCH, 2005, 33 (05) :349-357

[8]

Rad AK, 2011, UROL J, V8, P179

[9]

SAWAYA WN, 1983, J FOOD TECHNOL, V18, P183

[10] Calcium oxalate stone disease: role of lipid peroxidation and antioxidants [J].

Selvam, R .

UROLOGICAL RESEARCH, 2002, 30 (01) :35-47

← 1 2 →