Stimulation of cell component of the immune response activates exploratory behavior in senescence accelerated OXYS rats

被引：9

作者：

Markova, EV ^{[1
]}

Kozlov, VA

Trofimova, NA

Kolosova, NG

机构：

[1] Russian Acad Med Sci, Inst Clin Immunol, Siberian Div, Novosibirsk, Russia

[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2005年 / 140卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

orientation and exploratory behavior; immune response; delayed-type hypersensitivity; senescence accelerated OXYS rats;

D O I：

10.1007/s10517-005-0486-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Suppression of the cell component of the immune system and open-field behavior developing in OXYS rats by the age of 3 months are regarded as manifestations of accelerated aging. Stimulation of cell-mediated immune response with BCG vaccine caused a dose-dependent increase of orientation and exploratory activity of OXYS rats in the open field test to virtually the same level as in Wistar rats.

引用

页码：345 / 347

页数：3

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