TiO2 Nanotube Surfaces: 15 nm - An Optimal Length Scale of Surface Topography for Cell Adhesion and Differentiation

被引:458
作者
Park, Jung [2 ]
Bauer, Sebastian [1 ]
Schlegel, Karl Andreas
Neukam, Friedrich W.
von der Mark, Klaus [2 ]
Schmuki, Patrik [1 ]
机构
[1] Univ Erlangen Nurnberg, Dept Mat Sci, Inst Surface Sci & Corros LKO, D-91058 Erlangen, Germany
[2] Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, Dept Expt Med 1, D-91054 Erlangen, Germany
关键词
biomimetics; nanotubes; stem cells; surface topography; titanium dioxide; STEM-CELLS; BONE; PROLIFERATION; TITANIUM; SIZE; ELECTROLYTES; ACTIVATION; OXIDATION; MARROW; NICHE;
D O I
10.1002/smll.200801476
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An optimal length scale of surface topography for cell adhesion and differentiation of TiO2 surfaces was investigated in order to designate that the fabrication of ordered titanium dioxide nanotube layers with controlled diameters can be achieved by anodization of titanium adequate electrolytes. The focus was given to the interaction of osteoclasts with TiO2 nanoscale environments to explore the nanotopography of cell interactions and to maintain a balance between bone-forming and bone-resorbing cells. The experiments were carried out with TiO2 nanotubes with six different diameters, applied on the foils using an electrochemical cell with a three-electrode configuration. The results indicate that osteoclastic differentiation on large nanoporous structures is only temporarily impaired on 100nm nanotubes, whereas the size dependent response of HSCs to TiO2 nanotubes with respect to osteoclast differentiation.
引用
收藏
页码:666 / 671
页数:6
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