Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions

被引：146
作者：
Delgado, Mario [1 ]
Ganea, Doina [2 ]
机构：
[1] IPBLN CSIC, Inst Parasitol & Biomed, Granada, Spain
[2] Temple Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19122 USA
来源：
AMINO ACIDS | 2013年 / 45卷 / 01期
关键词：
Vasoactive intestinal peptide; Autoimmunity; Inflammation; Neuroinflammation; Neuropeptides/neurotransmitters; CYCLASE-ACTIVATING POLYPEPTIDE; REGULATORY DENDRITIC CELLS; MEKK1/MEK4/JNK SIGNALING PATHWAY; T-CELLS; CHEMOKINE PRODUCTION; INDUCED NEURODEGENERATION; EXPERIMENTAL ARTHRITIS; RHEUMATOID-ARTHRITIS; ALTERED EXPRESSION; CUTTING EDGE;
D O I：
10.1007/s00726-011-1184-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide/neurotransmitter, is widely distributed in both the central and peripheral nervous system. VIP is released by both neurons and immune cells. Various cell types, including immune cells, express VIP receptors. VIP has pleiotropic effects as a neurotransmitter, immune regulator, vasodilator and secretagogue. This review is focused on VIP production and effects on immune cells, VIP receptor signaling as related to immune functions, and the involvement of VIP in inflammatory and autoimmune disorders. The review addresses present clinical use of VIP and future therapeutic directions.
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收藏
页码：25 / 39
页数：15
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