Broad-coverage molecular epidemiology of Orientia tsutsugamushi in Thailand

被引：9

作者：

Wongprompitak, Patimapom ^{[1
]}

Anukool, Wichittra ^{[2
]}

Wongsawat, Ekkarat ^{[3
]}

Silpasakorn, Saowalak ^{[3
]}

Duong, Veasna ^{[4
]}

Buchy, Philippe ^{[4
]}

Morand, Serge ^{[5
]}

Frutos, Roger ^{[6
]}

Ekpo, Pattama ^{[1
]}

Suputtamongkol, Yupin ^{[3
]}

机构：

[1] Mahidol Univ, Fac Med, Siriraj Hosp, Dept Immunol, Bangkok 10700, Thailand

[2] Mahidol Univ, Fac Med, Siriraj Hosp, Grad Program Immunol, Bangkok 10700, Thailand

[3] Mahidol Univ, Fac Med, Siriraj Hosp, Dept Med, Bangkok 10700, Thailand

[4] Inst Pasteur Cambodia, Phnom Penh, Cambodia

[5] Univ Montpellier 2, CNRS UM2, Inst Sci Evolut ISE M, Montpellier, France

[6] CIRAD, UMR17, F-34093 Montpellier 5, France

来源：

INFECTION GENETICS AND EVOLUTION | 2013年 / 15卷

关键词：

Orientia tsutsugamushi; 56-kDa type specific antigen gene; Phylogenetic analysis; Genetic diversity; Thailand; 56 KDA PROTEIN; RICKETTSIA-TSUTSUGAMUSHI; SCRUB TYPHUS; ANTIGEN GENE; GEOGRAPHIC-DISTRIBUTION; SEQUENCE-ANALYSIS; DIVERSITY; IDENTIFICATION; RECOMBINATION; INDUCTION;

D O I：

10.1016/j.meegid.2011.06.008

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Orientia tsutsugamushi, an obligate intracellular bacterium closely related to the genus Rickettsia, is the causative agent of scrub typhus, a major cause of febrile illness in rural areas of Asia-Pacific region. Scrub typhus is transmitted by the bite of infected mites of the genus Leptotrombidium. The region of the 56-kDa TSA gene spanning from variable domain I (VDI) to variable domain IV (VDIV) was sequenced and used for genotyping 77 O. tsutsugamushi samples from human patients confirmed with scrub typhus from 2001 to 2003 and 2009 to 2010 in different regions of Thailand. These sequences were also compared to previously published 56-kDa TSA sequences. Only 4 genotypes out of 8 previously reported in Thailand were identified, i.e. Karp, JG-v, TA763 and Kato, respectively. Two strains were not associated with known genotypes but were closely related to Taiwanese strains. The Karp genotype was confirmed as the predominant clade. The JG-v and TA763 genotypes, in contrast to other studies, also were found. The genotype TA716 was not found, except for one strain previously described. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：53 / 58

页数：6

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