Mapping average axon diameters in porcine spinal cord white matter and rat corpus callosum using d-PFG MRI

被引：36

作者：

Komlosh, M. E. ^{[1
,2
]}

Oezarslan, E. ^{[1
,2
,3
]}

Lizak, M. J. ^{[4
]}

Horkayne-Szakaly, I. ^{[5
]}

Freidlin, R. Z. ^{[6
]}

Horkay, F. ^{[1
]}

Basser, P. J. ^{[1
]}

机构：

[1] NICHD, Sect Tissue Biophys & Biomimet, PPITS, NIH, Bethesda, MD 20892 USA

[2] Uniform Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA

[3] Harvard Univ, Brigham & Womens Hosp, Dept Radiol, Sch Med, Boston, MA 02215 USA

[4] NINDS, NIH MRI Res Facil, NIH, Bethesda, MD 20892 USA

[5] Dept Def, Joint Pathol Ctr, Silver Spring, MD 20910 USA

[6] NIH, Ctr Informat Technol, Bethesda, MD 20892 USA

来源：

NEUROIMAGE | 2013年 / 78卷

关键词：

MRI; Average axon diameter; AAD; Pulsed-field gradient; PFG; Double wave vector; d-PFG; dPFG; 3D; MICROSCOPIC DIFFUSION ANISOTROPY; COMPARTMENT SHAPE ANISOTROPY; WATER DIFFUSION; NMR; DIFFRACTION; TENSOR; SIZE; ECHOES;

D O I：

10.1016/j.neuroimage.2013.03.074

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Knowledge of microstructural features of nerve fascicles, such as their axon diameter, is crucial for understanding normal function in the central and peripheral nervous systems as well as assessing changes due to pathologies. In this study double-pulsed field gradient (d-PFG) filtered MRI was used to map the average axon diameter (AAD) in porcine spinal cord, which was then compared to AADs measured with optical microscopy of the same specimen, as a way to further validate this new MRI method. A novel 3D d-PFG acquisition scheme was used to obtain AADs in each voxel of a coronal slice of rat brain corpus callosum. AAD measurements were also acquired using optical microscopy performed on histological sections and validated using a glass capillary array phantom. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：210 / 216

页数：7

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