Anti-glioma trichobamide A with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729

被引：21

作者：

Chen, Senhua ^{[1
]}

Shen, Hongjie ^{[1
]}

Zhang, Panpan ^{[1
]}

Cheng, Hongwei ^{[2
]}

Dai, Xingliang ^{[2
]}

Liu, Lan ^{[1
,3
]}

机构：

[1] Sun Yat Sen Univ, Sch Marine Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Dept Neurosurg, Hefei 230032, Anhui, Peoples R China

[3] Sun Yat Sen Univ, Key Lab Funct Mol Ocean Microorganism, Dept Educ Guangdong Prov, Guangzhou 510080, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ANTITUBERCULAR ALKALOIDS; ENDOPHYTIC FUNGUS; A-C; PYRROSPIRONES; HIRSUTELLONES; METABOLITES;

D O I：

10.1039/c8cc08970a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trichobamide A (1), a novel pyrrocidine alkaloid with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one moiety, was isolated from the ascidian-derived fungus Trichobotrys effuse 4729. Trichobamide A (1) showed significant inhibition of the proliferation of two glioma cell lines, U251 and SNB19. It induced the up-regulation of P53 expression, which in turn induces the up-regulation of downstream pro-apoptotic gene expression and the down-regulation of anti-apoptotic gene expression.

引用

页码：1438 / 1441

页数：4

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