Parkinson's Disease and Mesenchymal Stem Cells: Potential for Cell-Based Therapy

被引：52
|
作者：
Kitada, Masaaki [1 ]
Dezawa, Mari [1 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Dept Stem Cell Biol & Histol, Sendai, Miyagi 9808575, Japan
来源：
PARKINSONS DISEASE | 2012年 / 2012卷
关键词：
MARROW STROMAL CELLS; MIDBRAIN DOPAMINERGIC-NEURONS; NEURAL PROGENITOR CELLS; LONG-TERM SURVIVAL; RAT MODEL; TISSUE-REPAIR; TUMOR-FORMATION; DOUBLE-BLIND; IN-VITRO; ES CELLS;
D O I：
10.1155/2012/873706
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cell transplantation is a strategy with great potential for the treatment of Parkinson's disease, and many types of stem cells, including neural stem cells and embryonic stem cells, are considered candidates for transplantation therapy. Mesenchymal stem cells are a great therapeutic cell source because they are easy accessible and can be expanded from patients or donor mesenchymal tissues without posing serious ethical and technical problems. They have trophic effects for protecting damaged tissues as well as differentiation ability to generate a broad spectrum of cells, including dopamine neurons, which contribute to the replenishment of lost cells in Parkinson's disease. This paper focuses mainly on the potential of mesenchymal stem cells as a therapeutic cell source and discusses their potential clinical application in Parkinson's disease.
引用
收藏
页数：9
相关论文
共 50 条
  • [1] Potential of Neural Stem Cell-Based Therapy for Parkinson's Disease
    Chou, Chung-Hsing
    Fan, Hueng-Chuen
    Hueng, Dueng-Yuan
    PARKINSONS DISEASE, 2015, 2015
  • [2] Stem cell-based therapy for Parkinson's disease
    Correia, AS
    Anisimov, SV
    Li, JY
    Brundin, P
    ANNALS OF MEDICINE, 2005, 37 (07) : 487 - 498
  • [3] Stem cell-based therapy for Parkinson's disease with a focus on human endometrium-derived mesenchymal stem cells
    Bagheri-Mohammadi, Saeid
    Karimian, Mohammad
    Alani, Behrang
    Verdi, Javad
    Tehrani, Rana Moradian
    Noureddini, Mahdi
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (02) : 1326 - 1335
  • [4] Mesenchymal Stem Cells as a Source of Dopaminergic Neurons: A Potential Cell Based Therapy for Parkinson's Disease
    Venkatesh, Katari
    Sen, Dwaipayan
    CURRENT STEM CELL RESEARCH & THERAPY, 2017, 12 (04) : 326 - 347
  • [5] Development of stem cell-based therapy for Parkinson's disease
    Han, Fabin
    Baremberg, Deborah
    Gao, Junyu
    Duan, Jing
    Lu, Xianjie
    Zhang, Nan
    Chen, Qingfa
    TRANSLATIONAL NEURODEGENERATION, 2015, 4
  • [6] A Neural Stem Cell-Based Therapy for Parkinson's Disease
    Gonzalez, R.
    Garitaonandia, I.
    Poustovoitov, M.
    Abramihina, T.
    McEntire, C. R.
    Culp, B.
    Attwood, J.
    Noskov, A.
    Semechkin, A.
    Laurent, L. C.
    Elsworth, J. D.
    Sladek, J.
    Snyder, E. Y.
    Redmond, D. E., Jr.
    Kern, R.
    CELL TRANSPLANTATION, 2016, 25 (04) : 758 - 759
  • [7] Development of stem cell-based therapy for Parkinson’s disease
    Fabin Han
    Deborah Baremberg
    Junyu Gao
    Jing Duan
    Xianjie Lu
    Nan Zhang
    Qingfa Chen
    Translational Neurodegeneration, 4
  • [8] An Update on Human Stem Cell-Based Therapy in Parkinson's Disease
    Gonzalez, Clara
    Bonilla, Sonia
    Isabel Flores, Ana
    Cano, Eva
    Liste, Isabel
    CURRENT STEM CELL RESEARCH & THERAPY, 2016, 11 (07) : 561 - 568
  • [9] Mesenchymal Stem Cells: An Overview of Their Potential in Cell-Based Therapy for Diabetic Nephropathy
    Wu, Yan
    Zhang, Chunlei
    Guo, Ran
    Wu, Dan
    Shi, Jiayi
    Li, Luxin
    Chu, Yanhui
    Yuan, Xiaohuan
    Gao, Jie
    STEM CELLS INTERNATIONAL, 2021, 2021
  • [10] Combined cell-based therapy strategies for the treatment of Parkinson's disease: focus on mesenchymal stromal cells
    Jannette Rodríguez-Pallares
    María García-Garrote
    Juan A.Parga
    José Luis Labandeira-García
    Neural Regeneration Research, 2023, (03) : 478 - 484
12345