Signaling of MiRNAs-FOXM1 in Cancer and Potential Targeted Therapy

被引：27
作者：
Shi, Min [1 ,3 ]
Cui, Jiujie [2 ,3 ]
Xie, Keping [3 ]
机构：
[1] Shanghai Jiao Tong Univ, Affiliated Ruijin Hosp, Dept Surg, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 1, Dept Oncol, Shanghai 200030, Peoples R China
[3] Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA
来源：
CURRENT DRUG TARGETS | 2013年 / 14卷 / 10期
基金：
美国国家卫生研究院;
关键词：
FOXM1; miRNA; transcription; invasion; metastasis; therapy; M1 TRANSCRIPTION FACTOR; MULTIVESICULAR BODIES; RETICULOCYTE MATURATION; DOWN-REGULATION; HEPATOCELLULAR CARCINOMAS; TRANSFERRIN RECEPTOR; MEMBRANE-VESICLES; EXOSOME SECRETION; DENDRITIC CELLS; GASTRIC-CANCER;
D O I：
10.2174/13894501113149990192
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The transcription factor Forkhead box protein M1 (FOXM1) is overexpressed in the majority of cancer patients. This overexpression is implicated to play a role in the pathogenesis, progression, and metastasis of cancer. This important role of FOXM1 demonstrates its significance to cancer therapy. MicroRNAs (miRNAs) are small noncoding, endogenous, single-stranded RNAs that are pivotal posttranscriptional gene expression regulators. MiRNAs aberrantly expressed in cancer cells have important roles in tumorigenesis and progression. Currently, miRNAs are being studied as diagnostic and prognostic biomarkers and therapeutic tools for cancer. The rapid discovery of many target miRNAs and their relevant pathways has contributed to the development of miRNA-based therapeutics for cancer. In this review, we summarize the latest and most significant findings on FOXM1 and miRNA involvement in cancer development and describe the role/roles of miRNA/FOXM1 signaling pathways in cancer initiation and progression. Targeting FOXM1 via regulation of miRNA expression may have a role in cancer treatment, although the miRNA delivery method remains the key challenge to the establishment of this novel therapy.
引用
收藏
页码：1192 / 1202
页数：11
相关论文
共 111 条
[51]   Biogenesis of small RNAs in animals [J].
Kim, V. Narry ;
Han, Jinju ;
Siomi, Mikiko C. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (02) :126-139
[52]   Intercellular Nanovesicle-Mediated microRNA Transfer: A Mechanism of Environmental Modulation of Hepatocellular Cancer Cell Growth [J].
Kogure, Takayuki ;
Lin, Wen-Lang ;
Yan, Irene K. ;
Braconi, Chiara ;
Patel, Tushar .
HEPATOLOGY, 2011, 54 (04) :1237-1248
[53]   FOXM1: From cancer initiation to progression and treatment [J].
Koo, Chuay-Yeng ;
Muir, Kyle W. ;
Lam, Eric W. -F. .
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2012, 1819 (01) :28-37
[54]   The human TRIDENT/HFH-11/FKHL16 gene:: Structure, localization, and promoter characterization [J].
Korver, W ;
Roose, J ;
Heinen, K ;
Weghuis, DO ;
de Bruijn, D ;
van Kessel, AG ;
Clevers, H .
GENOMICS, 1997, 46 (03) :435-442
[55]   Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs [J].
Kosaka, Nobuyoshi ;
Iguchi, Haruhisa ;
Yoshioka, Yusuke ;
Hagiwara, Keitaro ;
Takeshita, Fumitaka ;
Ochiya, Takahiro .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (02) :1397-1405
[56]   FoxM1: At the crossroads of ageing and cancer [J].
Laoukili, Jamila ;
Stahl, Marie ;
Medema, Rene H. .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2007, 1775 (01) :92-102
[57]   Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice [J].
Lespagnol, A. ;
Duflaut, D. ;
Beekman, C. ;
Blanc, L. ;
Fiucci, G. ;
Marine, J-C ;
Vidal, M. ;
Amson, R. ;
Telerman, A. .
CELL DEATH AND DIFFERENTIATION, 2008, 15 (11) :1723-1733
[58]   MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor [J].
Li, Jinsong ;
Huang, Hongzhang ;
Sun, Lijuan ;
Yang, Mei ;
Pan, Chaobin ;
Chen, Weiliang ;
Wu, Donghui ;
Lin, Zhaoyu ;
Zeng, Chunxian ;
Yao, Yandan ;
Zhang, Peter ;
Song, Erwei .
CLINICAL CANCER RESEARCH, 2009, 15 (12) :3998-4008
[59]   miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells [J].
Li, Jipeng ;
Wang, Yiping ;
Luo, Jianping ;
Fu, Zhongming ;
Ying, Jianfei ;
Yu, Yanhong ;
Yu, Wanjun .
FEBS LETTERS, 2012, 586 (20) :3761-3765
[60]   Critical Role and Regulation of Transcription Factor FoxM1 in Human Gastric Cancer Angiogenesis and Progression [J].
Li, Qiang ;
Zhang, Nu ;
Jia, Zhiliang ;
Le, Xiangdong ;
Dai, Bingbing ;
Wei, Daoyan ;
Huang, Suyun ;
Tan, Dongfeng ;
Xie, Keping .
CANCER RESEARCH, 2009, 69 (08) :3501-3509
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