Signaling of MiRNAs-FOXM1 in Cancer and Potential Targeted Therapy

被引：27

作者：

Shi, Min ^{[1
,3
]}

Cui, Jiujie ^{[2
,3
]}

Xie, Keping ^{[3
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Ruijin Hosp, Dept Surg, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 1, Dept Oncol, Shanghai 200030, Peoples R China

[3] Univ Texas MD Anderson Canc Ctr, Dept Gastroenterol Hepatol & Nutr, Houston, TX 77030 USA

来源：

CURRENT DRUG TARGETS | 2013年 / 14卷 / 10期

基金：

美国国家卫生研究院;

关键词：

FOXM1; miRNA; transcription; invasion; metastasis; therapy; M1 TRANSCRIPTION FACTOR; MULTIVESICULAR BODIES; RETICULOCYTE MATURATION; DOWN-REGULATION; HEPATOCELLULAR CARCINOMAS; TRANSFERRIN RECEPTOR; MEMBRANE-VESICLES; EXOSOME SECRETION; DENDRITIC CELLS; GASTRIC-CANCER;

D O I：

10.2174/13894501113149990192

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The transcription factor Forkhead box protein M1 (FOXM1) is overexpressed in the majority of cancer patients. This overexpression is implicated to play a role in the pathogenesis, progression, and metastasis of cancer. This important role of FOXM1 demonstrates its significance to cancer therapy. MicroRNAs (miRNAs) are small noncoding, endogenous, single-stranded RNAs that are pivotal posttranscriptional gene expression regulators. MiRNAs aberrantly expressed in cancer cells have important roles in tumorigenesis and progression. Currently, miRNAs are being studied as diagnostic and prognostic biomarkers and therapeutic tools for cancer. The rapid discovery of many target miRNAs and their relevant pathways has contributed to the development of miRNA-based therapeutics for cancer. In this review, we summarize the latest and most significant findings on FOXM1 and miRNA involvement in cancer development and describe the role/roles of miRNA/FOXM1 signaling pathways in cancer initiation and progression. Targeting FOXM1 via regulation of miRNA expression may have a role in cancer treatment, although the miRNA delivery method remains the key challenge to the establishment of this novel therapy.

引用

页码：1192 / 1202

页数：11

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