Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review

被引：93

作者：

An, Hyo Jin ^{[1
]}

Tizaoui, Kalthoum ^{[2
]}

Terrazzino, Salvatore ^{[3
,4
]}

Cargnin, Sarah ^{[3
,4
]}

Lee, Keum Hwa ^{[5
]}

Nam, Seoung Wan ^{[6
]}

Kim, Jae Seok ^{[7
]}

Yang, Jae Won ^{[7
]}

Lee, Jun Young ^{[7
]}

Smith, Lee ^{[8
]}

Koyanagi, Ai ^{[9
,10
]}

Jacob, Louis ^{[9
,11
]}

Li, Han ^{[12
]}

Shin, Jae Il ^{[5
]}

Kronbichler, Andreas ^{[13
]}

机构：

[1] Yonsei Univ, Coll Med, Seoul 03722, South Korea

[2] Univ Tunis El Manar, Sci Fac Tunis, Lab Microorganismes & Act Biomol, Tunis 2092, Tunisia

[3] Univ Piemonte Orientale, Dept Pharmaceut Sci, I-28100 Novara, Italy

[4] Univ Piemonte Orientale, Interdept Res Ctr Pharmacogenet & Pharmacogen CRI, I-28100 Novara, Italy

[5] Yonsei Univ, Dept Pediat, Coll Med, Seoul 03722, South Korea

[6] Yonsei Univ, Wonju Severance Christian Hosp, Dept Rheumatol, Wonju Coll Med, Wonju 26426, South Korea

[7] Yonsei Univ, Dept Nephrol, Wonju Coll Med, Wonju 26426, South Korea

[8] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge CB1 1PT, England

[9] CIBERSAM, Res & Dev Unit, Parc Sanitari St Joan Deu, Barcelona 08830, Spain

[10] ICREA, Pg Lluis Co 23, Barcelona 08010, Spain

[11] Univ Versailles St Quentin En Yvelines, Fac Med, F-78000 Versailles, France

[12] Univ Florida, Coll Med, Gainesville, FL 32610 USA

[13] Med Univ Innsbruck, Dept Internal Med Nephrol & Hypertens 4, A-6020 Innsbruck, Austria

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 16期

关键词：

sarcopenia; rheumatic disease; autoimmune disease; rheumatoid arthritis; inflammatory bowel disease; type; 1; diabetes; INFLAMMATORY-BOWEL-DISEASE; BODY-COMPOSITION PHENOTYPES; SKELETAL-MUSCLE DEPLETION; FREE MASS INDEX; SYSTEMIC-SCLEROSIS; GROWTH-FACTOR; DIABETES-MELLITUS; CROHNS-DISEASE; OLDER PERSONS; WORKING GROUP;

D O I：

10.3390/ijms21165678

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sarcopenia refers to a decrease in skeletal muscle mass and function. Because sarcopenia affects mortality, and causes significant disability, the clinical importance of sarcopenia is emerging. At first, sarcopenia was recognized as an age-related disease but, recently, it has been reported to be prevalent also in younger patients with autoimmune diseases. Specifically, the association of sarcopenia and autoimmune diseases such as rheumatoid arthritis has been studied in detail. Although the pathogenesis of sarcopenia in autoimmune diseases has not been elucidated, chronic inflammation is believed to contribute to sarcopenia, and moreover the pathogenesis seems to be different depending on the respective underlying disease. The definition of sarcopenia differs among studies, which limits direct comparisons. Therefore, in this review, we cover various definitions of sarcopenia used in previous studies and highlight the prevalence of sarcopenia in diverse autoimmune diseases including rheumatoid arthritis, spondyloarthritis, systemic sclerosis, inflammatory bowel disease, and autoimmune diabetes. In addition, we cover the pathogenesis and treatment of sarcopenia in autoimmune and rheumatic diseases. This review provides a comprehensive understanding of sarcopenia in various autoimmune diseases and highlights the need for a consistent definition of sarcopenia.

引用

页码：1 / 21

页数：21

共 122 条

[1] Sarcopenia Is Common in Overweight Patients with Inflammatory Bowel Disease and May Predict Need for Surgery [J].