The role of ubiquitin-proteasome system in glioma survival and growth

被引：9
|
作者：
Vlachostergios, Panagiotis J. [1 ]
Voutsadakis, Ioannis A. [2 ]
Papandreou, Christos N. [1 ]
机构：
[1] Univ Thessaly, Univ Hosp Larissa, Sch Hlth Sci, Dept Med Oncol,Fac Med, Biopolis 41110, Larissa, Greece
[2] CHU Vaudois, Ctr Pluridisciplinaire Oncol, CH-1011 Lausanne, Switzerland
来源：
GROWTH FACTORS | 2013年 / 31卷 / 03期
关键词：
Glioma; growth; proliferation; survival; ubiquitin-proteasome system; FACTOR-KAPPA-B; CELL-CYCLE PROGRESSION; NECROSIS-FACTOR-ALPHA; RECEPTOR-TYPE; TGF-BETA; GLIOBLASTOMA-MULTIFORME; TUMOR-SUPPRESSOR; MALIGNANT GLIOMA; C-MYC; NUCLEAR ACCUMULATION;
D O I：
10.3109/08977194.2013.799156
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
High-grade gliomas represent a group of aggressive brain tumors with poor prognosis due to an inherent capacity of persistent cell growth and survival. The ubiquitin-proteasome system (UPS) is an intracellular machinery responsible for protein turnover. Emerging evidence implicates various proteins targeted for degradation by the UPS in key survival and proliferation signaling pathways of these tumors. In this review, we discuss the involvement of UPS in the regulation of several mediators and effectors of these pathways in malignant gliomas.
引用
收藏
页码：106 / 113
页数：8
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