Clopidogrel Added to Aspirin Adds No Benefit but Bleeding Risk in Patients With Recent Lacunar Stroke

被引：11

作者：

Diener, Hans-Christoph ^{[1
,2
]}

Weber, Ralph ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Essen, Dept Neurol, D-45147 Essen, Germany

[2] Univ Hosp Essen, Stroke Ctr, D-45147 Essen, Germany

[3] Alfried Krupp Hosp Essen, Dept Neurol, Essen, Germany

来源：

STROKE | 2013年 / 44卷 / 03期

基金：

美国国家卫生研究院;

关键词：

aspirin; clopidogrel; lacunar stroke; randomized trial; stroke prevention; TRANSIENT ISCHEMIC ATTACK; SECONDARY PREVENTION; VORAPAXAR; THERAPY; EVENTS;

D O I：

10.1161/STROKEAHA.112.680751

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

[No abstract available]

引用

页码：861 / 863

页数：3

共 17 条

[1] Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack [J].

Adams, Robert J. ;

Albers, Greg ;

Alberts, Mark J. ;

Benavente, Oscar ;

Furie, Karen ;

Goldstein, Larry B. ;

Gorelick, Philip ;

Halperin, Jonathan ;

Harbaugh, Robert ;

Johnston, S. Claiborne ;

Katzan, Irene ;

Kelly-Hayes, Margaret ;

Kenton, Edgar J. ;

Marks, Michael ;

Sacco, Ralph L. ;

Schwamm, Lee H. .

STROKE, 2008, 39 (05) :1647-1652

[2] Effects of Clopidogrel Added to Aspirin in Patients with Recent Lacunar Stroke [J].

Benavente, Oscar R. ;

Hart, Robert G. ;

McClure, Leslie A. ;

Szychowski, Jeffrey M. ;

Coffey, Christopher S. ;

Pearce, Lesly A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (09) :817-825

[3] The Secondary Prevention of Small Subcortical Strokes (SPS3) study [J].

Benavente, Oscar R. ;

White, Carole L. ;

Pearce, Lesly ;

Pergola, Pablo ;

Roldan, Ana ;

Benavente, Marie-France ;

Coffey, Christopher ;

McClure, Leslie A. ;

Szychowski, Jeff M. ;

Conwit, Robin ;

Heberling, Patricia A. ;

Howard, George ;

Bazan, Carlos ;

Vidal-Pergola, Gabriela ;

Talbert, Robert ;

Hart, Robert G. .

INTERNATIONAL JOURNAL OF STROKE, 2011, 6 (02) :164-175

[4] Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events [J].

Bhatt, DL ;

Fox, KAA ;

Hacke, W ;

Berger, PB ;

Black, HR ;

Boden, WE ;

Cacoub, P ;

Cohen, EA ;

Creager, MA ;

Easton, JD ;

Flather, MD ;

Haffner, SM ;

Hamm, CW ;

Hankey, GJ ;

Johnston, SC ;

Mak, KH ;

Mas, JL ;

Montalescot, G ;

Pearson, TA ;

Steg, PG ;

Steinhubl, SR ;

Weber, MA ;

Brennan, DM ;

Fabry-Ribaudo, L ;

Booth, J ;

Topol, EJ ;

Frye, RL ;

Amarenco, P ;

Brass, LM ;

Buyse, M ;

Cohen, LS ;

DeMets, DL ;

Fuster, V ;

Hart, RG ;

Marler, JR ;

McCarthy, C ;

Schoemig, A ;

Lincoff, AM ;

Brener, SJ ;

Sila, CA ;

Albuquerque, A ;

Aroutiounov, G ;

Artemiev, D ;

Atkeson, BG ;

Bartel, T ;

Basart, DCG ;

Lima, AB ;

Belli, G ;

Bordalo e Sa, AL ;

Bosch, X .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (16) :1706-1717

[5] Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis [J].

Chimowitz, Marc I. ;

Lynn, Michael J. ;

Derdeyn, Colin P. ;

Turan, Tanya N. ;

Fiorella, David ;

Lane, Bethany F. ;

Janis, L. Scott ;

Lutsep, Helmi L. ;

Barnwell, Stanley L. ;

Waters, Michael F. ;

Hoh, Brian L. ;

Hourihane, J. Maurice ;

Levy, Elad I. ;

Alexandrov, Andrei V. ;

Harrigan, Mark R. ;

Chiu, David ;

Klucznik, Richard P. ;

Clark, Joni M. ;

McDougall, Cameron G. ;

Johnson, Mark D. ;

Pride, G. Lee, Jr. ;

Torbey, Michel T. ;

Zaidat, Osama O. ;

Rumboldt, Zoran ;

Cloft, Harry J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (11) :993-1003

[6] Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation [J].

Connolly, S. J. ;

Yusuf, S. ;

Camm, J. ;

Chrolavicius, S. ;

Commerford, P. ;

Flather, M. ;

Hart, R. G. ;

Hohnloser, S. H. ;

Joyner, C. ;

Pfeffer, M. ;

Gaudin, C. ;

Blumenthal, M. ;

Marchese, C. ;

Pogue, J. ;

Hart, R. ;

Hohnloser, S. ;

Anand, I. ;

Arthur, H. ;

Avezum, A. ;

Budaj, A. ;

Ceremuzynski, L. ;

De Caterina, R. ;

Diaz, R. ;

Dorian, P. ;

Flaker, G. ;

Fox, K. A. A. ;

Franzosi, M. G. ;

Goldhaber, S. ;

Golitsyn, S. ;

Granger, C. ;

Halon, D. ;

Hermosillo, A. ;

Hunt, D. ;

Jansky, P. ;

Karatzas, N. ;

Keltai, M. ;

Kozan, O. ;

Lanas, F. ;

Lau, P. ;

Le Heuzey, J. Y. ;

Lewis, B. S. ;

Morais, J. ;

Morillo, C. ;

Paolasso, E. ;

Peters, R. J. ;

Pfisterer, M. ;

Piegas, L. ;

Pipilis, A. ;

Sitkei, E. ;

Swedberg, K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (20) :2066-2078

[7] Secondary prevention in the acute and early chronic phase after ischaemic stroke and transient ischaemic attacks with antiplatelet drugs - is antiplatelet monotherapy still reasonable? [J].

Diener, H. C. ;

Weber, R. ;

Weimar, C. ;

Roether, J. .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2011, 65 (05) :531-535

[8] Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial [J].

Diener, HC ;

Bogousslavsky, J ;

Brass, LM ;

Cimminiello, C ;

Csiba, L ;

Kaste, M ;

Leys, D ;

Matias-Guiv, J ;

Rupprecht, HJ .

LANCET, 2004, 364 (9431) :331-337

[9] Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association [J].

Furie, Karen L. ;

Kasner, Scott E. ;

Adams, Robert J. ;

Albers, Gregory W. ;

Bush, Ruth L. ;

Fagan, Susan C. ;

Halperin, Jonathan L. ;

Johnston, S. Claiborne ;

Katzan, Irene ;

Kernan, Walter N. ;

Mitchell, Pamela H. ;

Ovbiagele, Bruce ;

Palesch, Yuko Y. ;

Sacco, Ralph L. ;

Schwamm, Lee H. ;

Wassertheil-Smoller, Sylvia ;

Turan, Tanya N. ;

Wentworth, Deidre .

STROKE, 2011, 42 (01) :227-276

[10] Triple antiplatelet therapy for preventing vascular events: a systematic review and meta-analysis [J].

Geeganage, Chamila ;

Wilcox, Robert ;

Bath, Philip M. W. .

BMC MEDICINE, 2010, 8

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