New Strategies in Pleural Mesothelioma: BAP1 and NF2 as Novel Targets for Therapeutic Development and Risk Assessment

被引：69

作者：

Ladanyi, Marc ^{[1
,2
]}

Zauderer, Marjorie G. ^{[5
,6
]}

Krug, Lee M. ^{[5
,6
]}

Ito, Tatsuo ^{[5
,6
]}

McMillan, Robert ^{[1
,2
,3
]}

Bott, Matthew ^{[3
]}

Giancotti, Filippo ^{[4
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10065 USA

[4] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA

[5] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

[6] Weill Cornell Med Coll, New York, NY USA

来源：

CLINICAL CANCER RESEARCH | 2012年 / 18卷 / 17期

关键词：

MALIGNANT MESOTHELIOMA; TUMOR-SUPPRESSOR; BRCA1-ASSOCIATED PROTEIN-1; PATHWAY ACTIVATION; GENE-EXPRESSION; UVEAL MELANOMA; MUTATIONS; GROWTH; COMPLEX; MTORC1;

D O I：

10.1158/1078-0432.CCR-11-2375

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant pleural mesothelioma (MPM) is a highly lethal cancer with limited therapeutic options. Recent work has focused on the frequent somatic inactivation of two tumor suppressor genes in MPM-NF2 (Neurofibromatosis type 2) and the recently identified BAP1 (BRCA associated protein 1). In addition, germline mutations in BAP1 have been identified that define a new familial cancer syndrome, which includes MPM, ocular melanoma, and other cancers. These recent advances may allow screening of high-risk individuals and the development of new therapies that target key pathways in MPM. Clin Cancer Res; 18(17); 4485-90. (C) 2012 AACR.

引用

页码：4485 / 4490

页数：6

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