Molecular linkage studies of bipolar disorders

被引：35

作者：

Berrettini, WH

机构：

[1] Univ Penn, Dept Psychiat, Philadelphia, PA 19107 USA

[2] Univ Penn, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA

来源：

BIPOLAR DISORDERS | 2001年 / 3卷 / 06期

关键词：

bipolar disorder; human genome; molecular linkage studies;

D O I：

10.1034/j.1399-5618.2001.30603.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: To review the reports of linkage findings for bipolar disorder. Methods: Literature review of published linkage findings in bipolar disorder. Results: There are several regions of the human genome that have been implicated repeatedly by independent investigators. These include 4p16, 12q24, 18q22, 18p11, 21q21 and 22q11. Two of these regions (18p11 and 22q11) are also implicated in genome scans of schizophrenia, suggesting that these two distinct nosological categories may share some genetic susceptibility. This hypothesis can only be tested when the underlying genes are identified.

引用

页码：276 / 283

页数：8

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