Exploring the origin of the cancer stem cell niche and its role in anti-angiogenic treatment for glioblastoma

被引：9
作者：
Akindona, Funto A. [1 ]
Frederico, Stephen C. [1 ,2 ]
Hancock, John C. [1 ,3 ,4 ]
Gilbert, Mark R. [1 ]
机构：
[1] NCI, Neurooncol Branch, Ctr Canc Res CCR, NIH, Bethesda, MD 20892 USA
[2] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA
[3] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England
[4] Univ Cambridge, Dept Clin Neurosci, Div Neurosurg, Cambridge, England
来源：
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词：
CNS; cancer stem cells (CSC); glioblastoma; GBM; CSC; INTUSSUSCEPTIVE MICROVASCULAR GROWTH; BEVACIZUMAB PLUS IRINOTECAN; VESSEL CO-OPTION; HEMATOPOIETIC STEM; SUBVENTRICULAR ZONE; PROGENITOR CELLS; VASCULAR NICHE; PERIVASCULAR NICHE; ENDOTHELIAL-CELLS; TUMOR ANGIOGENESIS;
D O I：
10.3389/fonc.2022.947634
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer stem cells are thought to be the main drivers of tumorigenesis for malignancies such as glioblastoma (GBM). They are maintained through a close relationship with the tumor vasculature. Previous literature has well-characterized the components and signaling pathways for maintenance of this stem cell niche, but details on how the niche initially forms are limited. This review discusses development of the nonmalignant neural and hematopoietic stem cell niches in order to draw important parallels to the malignant environment. We then discuss what is known about the cancer stem cell niche, its relationship with angiogenesis, and provide a hypothesis for its development in GBM. A better understanding of the mechanisms of development of the tumor stem cell niche may provide new insights to potentially therapeutically exploit.
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页数：11
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  • [11] Notch and Wnt signaling in the emergence of hematopoietic stem cells
    Bigas, Anna
    Guiu, Jordi
    Gama-Norton, Leonor
    [J]. BLOOD CELLS MOLECULES AND DISEASES, 2013, 51 (04) : 264 - 270
  • [12] Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors
    Bokstein, Felix
    Shpigel, Shulim
    Blumenthal, Deborah T.
    [J]. CANCER, 2008, 112 (10) : 2267 - 2273
  • [13] Ontogeny of adult neural stem cells in the mammalian brain
    Bond, Allison M.
    Ming, Guo-Li
    Song, Hongjun
    [J]. MOLECULAR MECHANISMS OF NEURAL DEVELOPMENT AND INSIGHTS INTO DISEASE, 2021, 142 : 67 - 98
  • [14] The hippocampal neurovascular niche during normal development and after irradiation to the juvenile mouse brain
    Bostrom, Martina
    Erkenstam, Nina Hellstrom
    Kaluza, David
    Jakobsson, Lars
    Kalm, Marie
    Blomgren, Klas
    [J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2014, 90 (09) : 778 - 789
  • [15] Bevacizumab: A treatment option for recurrent glioblastoma multiforme
    Buie, Larry W.
    Valgus, John M.
    [J]. ANNALS OF PHARMACOTHERAPY, 2008, 42 (10) : 1486 - 1490
  • [16] Direct contact with perivascular tumor cells enhances integrin βvβ3 signaling and migration of endothelial cells
    Burgett, Monica E.
    Lathia, Justin D.
    Roth, Patrick
    Nowacki, Amy S.
    Galileo, Deni S.
    Pugacheva, Elena
    Huang, Ping
    Vasanji, Amit
    Li, Meizhang
    Byzova, Tatiana
    Mikkelsen, Tom
    Bao, Shideng
    Rich, Jeremy N.
    Weller, Michael
    Gladson, Candece L.
    [J]. ONCOTARGET, 2016, 7 (28) : 43852 - 43867
  • [17] Breast cancer stem cells: Biology and therapeutic implications
    Butti, Ramesh
    Gunasekaran, Vinoth Prasanna
    Kumar, Totakura V. S.
    Banerjee, Pinaki
    Kundu, Gopal C.
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2019, 107 : 38 - 52
  • [18] The cancer stem cell niche-there goes the neighborhood?
    Cabarcas, Stephanie M.
    Mathews, Lesley A.
    Farrar, William L.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2011, 129 (10) : 2315 - 2327
  • [19] A perivascular niche for brain tumor stem cells
    Calabrese, Christopher
    Poppleton, Helen
    Kocak, Mehmet
    Hogg, Twala L.
    Fuller, Christine
    Hamner, Blair
    Oh, Eun Young
    Gaber, M. Waleed
    Finklestein, David
    Allen, Meredith
    Frank, Adrian
    Bayazitov, Ildar T.
    Zakharenko, Stanislav S.
    Gajjar, Amar
    Davidoff, Andrew
    Gilbertson, Richard J.
    [J]. CANCER CELL, 2007, 11 (01) : 69 - 82
  • [20] Glioblastoma Multiforme and Adult Neurogenesis in the Ventricular-Subventricular Zone: A Review
    Capdevila, Claudia
    Rodriguez Vazquez, Lucia
    Marti, Joaquin
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2017, 232 (07) : 1596 - 1601
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