Genetic variants associated with cisplatin-induced ototoxicity

被引：22

作者：

Oldenburg, Jan ^{[1
,2
]}

Fossa, Sophie D. ^{[1
,2
]}

Ikdahl, Tone ^{[3
]}

机构：

[1] Univ Oslo, Rikshosp, Norwegian Radium Hosp, Dept Clin Canc Res, N-0310 Oslo, Norway

[2] Univ Oslo, Norwegian Radium Hosp, Fac Div, N-0316 Oslo, Norway

[3] Ullevaal Univ Hosp, Ulleval Canc Ctr, Oslo, Norway

来源：

PHARMACOGENOMICS | 2008年 / 9卷 / 10期

关键词：

audiometric; chemotherapy; cisplatin; glutathione; GST; GSTM1; GSTP1; hearing impairment; hearing loss; ototoxicity; pharmacogenetics; polymorphism; tinnitus;

D O I：

10.2217/14622416.9.10.1521

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cisplatin induces ototoxicity with a huge interindividual variation, which is at least partly based on genetic differences between the affected individuals. Identification of genetic variants that could predict the severity of ototoxicity is an important step towards a more individualized cisplatin treatment. Nevertheless, so far, only a few studies have assessed this issue. This review will address the prevalence of cisplatin-induced ototoxicity, its pathophysiology, quantification and associations with genetic variants. The recent progress in both phenotyping and genotyping is discussed.

引用

页码：1521 / 1530

页数：10

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