Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

被引：428

作者：

Swartz, Melody A. ^{[1
,2
]}

Iida, Noriho ^{[3
]}

Roberts, Edward W. ^{[4
]}

Sangaletti, Sabina ^{[5
]}

Wong, Melissa H. ^{[6
]}

Yull, Fiona E. ^{[7
]}

Coussens, Lisa M. ^{[6
]}

DeClerck, Yves A. ^{[8
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Bioengn, Lausanne, Switzerland

[2] Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res, Lausanne, Switzerland

[3] NCI, NIH, Bethesda, MD 20892 USA

[4] Univ Cambridge, Cambridge, England

[5] Fdn IRCCS Inst Nazl Tumori, Milan, Italy

[6] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[7] Vanderbilt Univ, Nashville, TN USA

[8] Univ So Calif, Los Angeles, CA USA

来源：

CANCER RESEARCH | 2012年 / 72卷 / 10期

关键词：

BREAST-CANCER; LYMPHATIC VESSELS; METASTASIS; CELLS; INFLAMMATION; MACROPHAGES; INFECTION; STROMA;

D O I：

10.1158/0008-5472.CAN-12-0122

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumor microenvironment (TME) consists of cells, soluble factors, signaling molecules, extracellular matrix, and mechanical cues that can promote neoplastic transformation, support tumor growth and invasion, protect the tumor from host immunity, foster therapeutic resistance, and provide niches for dormant metastases to thrive. An American Association for Cancer Research (AACR) special conference held on November 3-6, 2011, addressed five emerging concepts in our understanding of the TME: its dynamic evolution, how it is educated by tumor cells, pathways of communication between stromal and tumor cells, immunomodulatory roles of the lymphatic system, and contribution of the intestinal microbiota. These discussions raised critical questions on how to include the analysis of the TME in personalized cancer diagnosis and treatment. Cancer Res; 72(10); 2473-80. (C) 2012 AACR.

引用

页码：2473 / 2480

页数：8

共 38 条

[1] Alitalo A, 2011, ONCOGENE
[2] Inflammation meets cancer, with NF-κB as the matchmaker
Ben-Neriah, Yinon
Karin, Michael
[J]. NATURE IMMUNOLOGY, 2011, 12 (08) : 715 - 723
[3] Breast cancer - one term, many entities?
Bertos, Nicholas R.
Park, Morag
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (10) : 3789 - 3796
[4] Borges VF, 2011, CANCER
[5] Cell communication networks in cancer invasion
Calvo, Fernando
Sahai, Erik
[J]. CURRENT OPINION IN CELL BIOLOGY, 2011, 23 (05) : 621 - 629
[6] Mesenchymal Stromal Cell Mutations and Wound Healing Contribute to the Etiology of Desmoid Tumors
Carothers, Adelaide M.
Rizvi, Hira
Hasson, Rian M.
Heit, Yvonne I.
Davids, Jennifer S.
Bertagnolli, Monica M.
Cho, Nancy L.
[J]. CANCER RESEARCH, 2012, 72 (01) : 346 - 355
[7] NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model
Connelly, Linda
Barham, Whitney
Onishko, Halina M.
Chen, Lianyi
Sherrill, Taylor P.
Zabuawala, Tahera
Ostrowski, Michael C.
Blackwell, Timothy S.
Yull, Fiona E.
[J]. BREAST CANCER RESEARCH, 2011, 13 (04):
[8] Cancer therapy - Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
Coussens, LM
Fingleton, B
Matrisian, LM
[J]. SCIENCE, 2002, 295 (5564) : 2387 - 2392
[9] Interleukin-6 as a Therapeutic Target in Human Ovarian Cancer
Coward, Jermaine
Kulbe, Hagen
Chakravarty, Probir
Leader, David
Vassileva, Vessela
Leinster, D. Andrew
Thompson, Richard
Schioppa, Tiziana
Nemeth, Jeffery
Vermeulen, Jessica
Singh, Naveena
Avril, Norbert
Cummings, Jeff
Rexhepaj, Elton
Jirstrom, Karin
Gallagher, William M.
Brennan, Donal J.
McNeish, Iain A.
Balkwill, Frances R.
[J]. CLINICAL CANCER RESEARCH, 2011, 17 (18) : 6083 - 6096
[10] Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
DeNardo, David G.
Brennan, Donal J.
Rexhepaj, Elton
Ruffell, Brian
Shiao, Stephen L.
Madden, Stephen F.
Gallagher, William M.
Wadhwani, Nikhil
Keil, Scott D.
Junaid, Sharfaa A.
Rugo, Hope S.
Hwang, E. Shelley
Jirstroem, Karin
West, Brian L.
Coussens, Lisa M.
[J]. CANCER DISCOVERY, 2011, 1 (01) : 54 - 67

← 1 2 3 4 →