Mechanism of V(D)J recombination

被引：88
作者：
Bogue, M
Roth, DB
机构：
[1] Dept. of Microbiology and Immunology, Baylor College of Medicine, Immunology M929, Houston, TX 77030
来源：
CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 02期
关键词：
D O I：
10.1016/S0952-7915(96)80055-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
V(D)J recombination can be separated into two basic operations: DNA cleavage and joining of broken ends. Our understanding of both reactions has increased substantially in the past year, Major advances include the development of a cell-free system capable of cleavage and the identification of several proteins involved in both V(D)J recombination and double-strand break repair.
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页码：175 / 180
页数：6
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