Leptin promotes bone metastasis of breast cancer by activating the SDF-1/CXCR4 axis

被引：8

作者：

Duan, Lixia ^{[1
]}

Lu, Yongkui ^{[1
]}

Xie, Weimin ^{[1
]}

Nong, Li ^{[1
]}

Jia, Yuxian ^{[1
]}

Tan, Aihua ^{[1
]}

Liu, Yan ^{[1
,2
,3
]}

机构：

[1] Guangxi Med Univ, Affiliated Tumor Hosp, Dept Chemotherapy 5, Nanning, Peoples R China

[2] Guangxi Med Univ, Affiliated Hosp 5, Dept Trauma Orthoped & Hand Surg, Nanning, Peoples R China

[3] Guangxi Med Univ, Guangxi Key Lab Regenerat Med, Nanning, Peoples R China

来源：

AGING-US | 2020年 / 12卷 / 16期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

leptin; breast cancer; bone metastasis; SDF-1/CXCR4; axis; EPITHELIAL-MESENCHYMAL TRANSITION; CHEMOKINE RECEPTOR CXCR4; DOWN-REGULATION; OBESITY; INVOLVEMENT; EXPRESSION;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity is associated with an increased risk of tumorigenesis, and increased leptin levels can promote tumor metastasis. However, the effects of leptin on bone metastasis in breast cancer are not fully understood. Here, we examined leptin receptor expression and bone metastasis in tissue samples from 96 breast cancer patients. In addition, we investigated the effects of leptin on the metastatic capacity of breast cancer cells in vitro using a transwell assays. The results indicated that higher leptin receptor levels in breast cancer cells are associated with increased incidence of bone metastasis in breast cancer patients. Additionally, leptin promoted migration and invasion of breast cancer cells. The SDF-1/CXCR4 axis activated by leptin also promoted bone metastasis of breast cancer. Finally, increased CXCR4 expression was accompanied by high leptin receptor expression in bone metastatic tissues from breast cancer patients. These results indicate that leptin induces bone metastasis of breast cancer by activating the SDF-1/CXCR4 axis.

引用

页码：16172 / 16182

页数：11

共 36 条

[1] The multifactorial role of leptin in driving the breast cancer microenvironment [J].

Ando, Sebastiano ;

Catalano, Stefania .

NATURE REVIEWS ENDOCRINOLOGY, 2012, 8 (05) :263-275

[2] Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms [J].

Babic, Ana ;

Bao, Ying ;

Qian, Zhi Rong ;

Yuan, Chen ;

Giovannucci, Edward L. ;

Aschard, Hugues ;

Kraft, Peter ;

Amundadottir, Laufey T. ;

Stolzenberg-Solo-mon, Rachael ;

Morales-Oyarvide, Vicente ;

Ng, Kimmie ;

Stampfer, Meir J. ;

Ogino, Shuji ;

Buring, Julie E. ;

Sesso, Howard D. ;

Gaziano, John Michael ;

Rifai, Nader ;

Pollak, Michael N. ;

Anderson, Matthew L. ;

Cochrane, Barbara B. ;

Luo, Juhua ;

Manson, JoAnn E. ;

Fuchs, Charles S. ;

Wolpin, Brian M. .

CANCER RESEARCH, 2016, 76 (24) :7160-7167

[3] Leptin, obesity and breast cancer: progress to understanding the molecular connections [J].

Barone, Ines ;

Giordano, Cinzia ;

Bonofiglio, Daniela ;

Ando, Sebastiano ;

Catalano, Stefania .

CURRENT OPINION IN PHARMACOLOGY, 2016, 31 :83-89

[4]

Coleman RE, 1997, CANCER, V80, P1588, DOI 10.1002/(SICI)1097-0142(19971015)80:8+<1588::AID-CNCR9>3.3.CO

[5]

2-Z

[6] Leptin and cancer [J].

Garofalo, C ;

Surmacz, E .

JOURNAL OF CELLULAR PHYSIOLOGY, 2006, 207 (01) :12-22

[7] Insulin- and Obesity-Related Variables in Early-Stage Breast Cancer: Correlations and Time Course of Prognostic Associations [J].

Goodwin, Pamela J. ;

Ennis, Marguerite ;

Pritchard, Kathleen I. ;

Trudeau, Maureen E. ;

Koo, Jarley ;

Taylor, Sara K. ;

Hood, Nicky .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (02) :164-171

[8] Obesity and breast cancer: status of leptin and adiponectin in pathological processes [J].

Grossmann, Michael E. ;

Ray, Amitabha ;

Nkhata, Katai J. ;

Malakhov, Dmitry A. ;

Rogozina, Olga P. ;

Dogan, Soner ;

Cleary, Margot P. .

CANCER AND METASTASIS REVIEWS, 2010, 29 (04) :641-653

[9] Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells [J].

Guo, Shanchun ;

Liu, Mingli ;

Wang, Guangdi ;

Torroella-Kouri, Marta ;

Gonzalez-Perez, Ruben R. .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1825 (02) :207-222

[10] Notch, IL-1 and Leptin Crosstalk Outcome (NILCO) Is Critical for Leptin-Induced Proliferation, Migration and VEGF/VEGFR-2 Expression in Breast Cancer [J].

Guo, Shanchun ;

Gonzalez-Perez, Ruben R. .

PLOS ONE, 2011, 6 (06)

← 1 2 3 4 →