Reverse Translation for Assessment of Confidence in Animal Models of Multiple Sclerosis for Drug Discovery

被引：8

作者：

't Hart, Bert A. ^{[1
,2
,3
]}

Laman, Jon D. ^{[2
,3
]}

Kap, Yolanda S. ^{[1
]}

机构：

[1] Biomed Primate Res Ctr, Dept Immunobiol, Rijswijk, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, Groningen, Netherlands

[3] MS Ctr Noord Nederland, Groningen, Netherlands

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2018年 / 103卷 / 02期

关键词：

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; B-CELL DEPLETION; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; COMMON MARMOSETS; PRIMATE MODEL; T-CELLS; DOUBLE-BLIND; CNS MYELIN; ANTIBODY; DISEASE;

D O I：

10.1002/cpt.801

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The poor predictive quality of currently used animal models in preclinical research is an important cause of the high attrition of promising drug candidates for human autoimmune disease in clinical trials. Examples from own work in a primate multiple sclerosis (MS) model illustrate that important lessons can be learned from a critical reassessment of failed drugs in the animal model, which can help improve the animal model and better understand the targeted disease.

引用

页码：262 / 270

页数：9

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